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Comparison of antigenic mutation during egg and cell passage cultivation of H3N2 influenza virus

Park YW, Kim YH, Jung HU, Jeong OS, Hong EJ, Kim H, Lee JI

PURPOSE: When influenza viruses are cultured in eggs, amino acid mutations of the hemagglutinin may occur through egg adaptation. On the other hand, when influenza viruses are cultured in animal...
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Antibody responses after vaccination against equine influenza in Korea in 2016–2018

Equine influenza (EI) is the main cause of respiratory illness in equines across the globe and is caused by equine influenza A virus (EIV-A), which has impacted the equine industry...
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Estimating Influenza-associated Mortality in Korea: The 2009–2016 Seasons

Hong K, Sohn S, Chun BC

OBJECTIVES: Estimating influenza-associated mortality is important since seasonal influenza affects persons of all ages, causing severe illness or death. This study aimed to estimate influenza-associated mortality, considering both periodic changes...
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Transient expression of hemagglutinin antigen from canine influenza virus H3N2 in Nicotiana benthamiana and Lactuca sativa

Maharjan P, Choe S

PURPOSE: Canine influenza virus (CIV), H3N2, carries potentiality for zoonotic transmission and genetic assortment which raises a concern on possible epidemics, and human threats in future. To manage possible threats,...
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Comparison of clinical severity between single- and coinfections of respiratory syncytial virus and influenza virus with common respiratory viruses

Park JS, Chu SY, Shin YY, Ryu IK, Tang CL, Choi J, Kim HB, Kim CK

PURPOSE: Multiple virus infections may affect clinical severity. We investigated the effect of coinfection of respiratory syncytial virus (RSV) and influenza virus with other respiratory viruses on clinical severity. METHODS: Data...
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Bacterial and Viral Identification Rate in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Korea

Choi J, Oh JY, Lee YS, Hur GY, Lee SY, Shim JJ, Kang KH, Min KH

PURPOSE: The most common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is respiratory infection. Most studies of bacterial or viral cause in AECOPD have been conducted in...
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A Study on Factors Associated with Duration of Influenza Virus Shedding in Children

Oh SR, Son BH, Lee KW

To prevent the spread of influenza among infants and adolescents attending kindergartens and schools, proper quarantining of those who are ill is necessary. In this study, the rapid antigen test...
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A Study on Factors Associated with Duration of Influenza Virus Shedding in Children

Oh SR, Son BH, Lee KW

To prevent the spread of influenza among infants and adolescents attending kindergartens and schools, proper quarantining of those who are ill is necessary. In this study, the rapid antigen test...
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A Study on Factors Associated with Duration of Influenza Virus Shedding in Children

Oh SR, Son BH, Lee KW

To prevent the spread of influenza among infants and adolescents attending kindergartens and schools, proper quarantining of those who are ill is necessary. In this study, the rapid antigen test...
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Evaluation of Waning Immunity at 6 Months after Both Trivalent and Quadrivalent Influenza Vaccination in Korean Children Aged 6–35 Months

Lee JH, Cho HK, Kim KH, Lee J, Kim YJ, Eun BW, Kim NH, Kim DH, Jo DS, Kim HM, Kim YK

BACKGROUND: The titer of influenza vaccine-induced antibodies declines over time, and younger children have lower immunogenicity and shorter duration of immunity. This study aimed to compare persistence of antibody at...
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Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types

Kim JJ, Kim KS, Eom J, Lee JB, Seo JY

Viperin is an IFN-stimulated gene (ISG)-encoded protein that was identified in human primary macrophages treated with IFN-γ and in human primary fibroblasts infected with cytomegalovirus (CMV). This protein plays multiple...
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Characteristics and Outcomes of Patients with Pulmonary Acute Respiratory Distress Syndrome Infected with Influenza versus Other Respiratory Viruses

Yoo JW, Ju S, Lee SJ, Cho MC, Cho YJ, Jeong YY, Lee JD, Kim HC

BACKGROUND: Although the frequency of respiratory viral infection in patients with pulmonary acute respiratory distress syndrome (ARDS) is not uncommon, clinical significance of the condition remains to be further elucidated....
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Development of a HA1-specific enzyme-linked immunosorbent assay against pandemic influenza virus A H1N1

Shim DH, Kim MJ, Cha HR, Park ES, Kim AR, Park JH, Park HC, Song D, Lee JM

PURPOSE: Enzyme-linked immunosorbent assay (ELISA) has been used in the diverse field to evaluate influenza virus infection; for the surveillance, diagnosis, efficacy evaluation, and development of the vaccine. The aim...
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Modification of the Conventional Influenza Epidemic Models Using Environmental Parameters in Iran

Naserpor A, Niakan Kalhori SR, Ghazisaeedi M, Azizi R, Hosseini Ravandi M, Sharafie S

OBJECTIVES: The association between the spread of infectious diseases and climate parameters has been widely studied in recent decades. In this paper, we formulate, exploit, and compare three variations of...
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Seasonality and etiology of croup in pediatric patients hospitalized with lower respiratory tract infections: A long-term study between 2009 and 2017

Oh KJ, Yang DH, Shin HR, Kim EJ, Sun YH, Ryoo E, Cho HK, Cho HJ

PURPOSE: Croup is a common respiratory disease in children. The aim of this study was to analyze the epidemiology, etiology, and seasonal variations of respiratory virus infections in children with...
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Kinetic Studies and Infection Control of Respiratory Viruses

Kim SK, Sung H, Kim MN

The importance of infection control has been increasingly recognized after the Middle East respiratory syndrome (MERS) outbreak in Korea. Infection management guidelines are based on viral pathway and kinetic studies....
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Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection

Choi E, Ha KS, Song DJ, Lee JH, Lee KC

PURPOSE: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in...
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Epidemiology and Clinical Severity of the Hospitalized Children with Viral Croup

Jeon IS, Cho WJ, Lee J, Kim HM

PURPOSE: In this study, the clinical and epidemiological characteristics of patients admitted for viral croup were analyzed to evaluate disease severity based on the organism that caused the infection. METHODS: We...
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The anti-Influenza effect of a water soluble herbal extract from Salvia miltiorrhiza (Danshen) in vivo

Lee ES, Kim MS, Weeratunga P, Lee HC, Chathuranga K, Ma JY, Kim HI, Lee JS

Salvia miltiorrhiza (Danshen) is perennial plant and commonly used in traditional Chinese medicine to treat numerous diseases like cardiovascular and cerebrovascular diseases, coronary heart disease, myocardial infarction, stroke and some...
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Hospital-based Influenza Morbidity and Mortality (HIMM) Surveillance for A/H7N9 Influenza Virus Infection in Returning Travelers

Song JY, Noh JY, Lee J, Woo HJ, Lee JS, Wie SH, Kim YK, Jeong HW, Kim SW, Lee SH, Park KH, Kang SH, Kee SY, Kim TH, Choo EJ, Lee HS, Choi WS, Cheong HJ, Kim WJ

Since 2013, the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system began a H7N9 influenza surveillance scheme for returning travelers in addition to pre-existing emergency room (ER)-based influenza-like illness (ILI)...
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