J Korean Soc Traumatol.  2018 Dec;31(3):166-173. 10.20408/jti.2018.027.

Significance of Biomarkers as a Predictive Factor for Post-Traumatic Sepsis

• Lee KW
• Choi SH
• Yoon YH
• Kim JY
• Cho YD
• Cho HJ
• Park SJ

• KMID: 2437280
• DOI: http://doi.org/10.20408/jti.2018.027

Abstract

PURPOSE
Many traumatic patients die from sepsis and multiple organ failure. Early recognition of post-traumatic sepsis in traumatic patients will help improve the prognosis. Recently, procalcitonin (PCT), macrophage migration inhibitory factor (MIF), and lactic acid have emerged as predictive factors. Our study aims to explore the significance of PCT, MIF and lactic acid as a predictor of posttraumatic-sepsis in trauma patients.
METHODS
This study was conducted on prospective observational study patients who visited an emergency medical center in a university hospital from March 2014 to February 2016. We measured the white blood cells, c-reactive protein (CRP), lactic acid, PCT, and MIF with serum taken from the patient's blood within 1 hour of the occurrence of the trauma. The definition of post-traumatic sepsis was defined as being part of systemic inflammation response syndrome criteria with infections within a week.
RESULTS
A total of 132 patients were analyzed, wherein 74 patients were included in the low injury severity score (ISS) group (ISS < 15) and 58 patients were included in the high ISS group (ISS ≥15). The mean PCT, MIF, and lactic acid levels were higher in the high ISS group (p < 0.05). Meanwhile, 38 patients were included in the early sepsis group and 94 patients were included in the non-sepsis group. The mean MIF levels were higher in the sepsis group than the non-sepsis group (p < 0.05) and there were no significant differences in the initial CRP, lactic acid, and PCT levels in these two groups.
CONCLUSIONS
MIF may be considered as a predictive factor for sepsis in trauma patients.

Keyword

Injury; Sepsis; Macrophage migration-inhibitory factors; Procalcitonin; Lactic acid

MeSH Terms

Biomarkers*
C-Reactive Protein
Emergencies
Humans
Inflammation
Injury Severity Score
Lactic Acid
Leukocytes
Macrophage Migration-Inhibitory Factors
Macrophages
Multiple Organ Failure
Observational Study
Prognosis
Prospective Studies
Sepsis*
Biomarkers
C-Reactive Protein
Lactic Acid
Macrophage Migration-Inhibitory Factors