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Macrophage migration inhibitory factor: a potential therapeutic target for rheumatoid arthritis

Kim KW, Kim HR

Macrophage migration inhibitory factor (MIF) is originally identified in the culture medium of activated T lymphocytes as a soluble factor that inhibits the random migration of macrophages. MIF is now...
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The macrophage migration inhibitory factor protein superfamily in obesity and wound repair

Kim BS, Pallua N, Bernhagen , Bucala R

The rising number of obese individuals has become a major burden to the healthcare systems worldwide. Obesity includes not only the increase of adipose tissue mass but importantly also the...
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The Association of Higher Plasma Macrophage Migration Inhibitory Factor Levels with Lower Bone Mineral Density and Higher Bone Turnover Rate in Postmenopausal Women

Kim H, Ahn SH, Shin C, Lee SH, Kim BJ, Koh JM

BACKGROUND: Despite evidence from animal and clinical studies showing the detrimental effects of macrophage migration inhibitory factor (MIF) on bone metabolism, there are no clinical studies relating circulating MIF levels...
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Effect of hypertonic saline and macrophage migration inhibitory factor in restoration of T cell dysfunction

Yoon YH, Choi SH, Hong YS, Lee SW, Moon SW, Cho HJ, Han C, Cheon YJ, Bansal V

PURPOSE: Trauma-induced suppression of cellular immune function likely contributes to sepsis, multiple organ dysfunction syndrome and death. T cell proliferation decreases after traumatic stress. The addition of prostaglandin E2 (PGE2),...
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Significance of Biomarkers as a Predictive Factor for Post-Traumatic Sepsis

Lee KW, Choi SH, Yoon YH, Kim JY, Cho YD, Cho HJ, Park SJ

PURPOSE: Many traumatic patients die from sepsis and multiple organ failure. Early recognition of post-traumatic sepsis in traumatic patients will help improve the prognosis. Recently, procalcitonin (PCT), macrophage migration inhibitory...
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Hypertonic saline downregulate the production level of lipopolysaccharide-induced migration inhibitory factor in THP-1 cells

Han C, Choi SH, Yoon YH, Cho YD, Kim JY, Hong YS, Lee SW, Moon SW, Cho HJ, Cheon YJ

PURPOSE: Macrophage migration inhibitory factor (MIF) may serve as a general marker for systemic inflammation in septic and nonseptic acute critical illness. Additionally, our previous experiment has demonstrated that immunosuppressant...
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Effect of Macrophage Migration Inhibitory Factor on Corneal Sensitivity after Laser In Situ Keratomileusis in Rabbit

Hyon JY, Hose S, Gongora C, Sinha D, O'Brien T

PURPOSE: To investigate the effect of macrophage migration inhibitory factor (MIF) on corneal sensitivity after laser in situ keratomileusis (LASIK) surgery. METHODS: New Zealand white rabbits were used in this study....
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Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway

Kim HR, Park MK, Cho ML, Kim KW, Oh HJ, Park JS, Heo YM, Lee SH, Kim HY, Park SH

BACKGROUND/AIMS: This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. METHODS: Human RA...
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