J Korean Orthop Assoc.  1994 Feb;29(1):44-49. 10.4055/jkoa.1994.29.1.44.

Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Erythrocytes and Synovial Fluid of the Osteoarthritis of the Knee Joint

• Shin DM
• Moon YR
• Lee BR

• KMID: 2423035
• DOI: http://doi.org/10.4055/jkoa.1994.29.1.44

Abstract

Superoxide dismutase(SOD), catalase and glutathione peroxidase and the levels of lipid peroxide were assayed in erythrocytes and synovial fluid isolated from 17 patients with osteoarthritis of the knee joints and 7 with healthy knee joints as a control groups. In the erythrocytes, SOD, catalase and glutathione peroxidase activities were significantly increased in osteoarthritis compared with normal control groups, but the changes of malonyldialdehyde level was not significant. The activity of SOD in synovial fluid was significantly decreased in osteoarthritis compared with normal control groups, but catalase activity was significantly increased in synovial fluid of osteoarthritis. This result suggested that the increament of antioxidant enzymes in erythrocytes were probably due to increased production of oxygen radicals in osteoarthritis. In osteoarthritis, knee joints might be injured more easily by oxygen radicals because of decreased activity of SOD in synovial fluid of osteoarthritis.

Keyword

Osteoarthritis; Antioxidant enzymes

MeSH Terms

Catalase*
Erythrocytes*
Glutathione Peroxidase*
Glutathione*
Humans
Joints
Knee Joint*
Knee*
Malondialdehyde
Osteoarthritis*
Osteoarthritis, Knee
Reactive Oxygen Species
Superoxide Dismutase*
Superoxides*
Synovial Fluid*
Catalase
Glutathione
Glutathione Peroxidase
Malondialdehyde
Reactive Oxygen Species
Superoxide Dismutase
Superoxides