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Intra-Articular Atelocollagen Injection for the Treatment of Articular Cartilage Defects in Rabbit Model

Suh DS, Yoo JC, Woo SH, Kwak AS

BACKGROUND: Atelocollagen is widely recognized as a biomaterial for regenerative medicine because of its good compatibility and low antigenicity. Injury of the outermost layer of articular cartilage, known as the...
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Exosomes from IL-1b-Primed Mesenchymal Stem Cells Inhibited IL-1b- and TNF-a-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells

Kim M, Shin DI, Choi BH, Min BH

BACKGROUND: Exosomes from mesenchymal stem cells (MSCs) show anti-inflammatory effect on osteoarthritis (OA); however, their biological effect and mechanism are not yet clearly understood. This study investigated the anti-inflammatory effect and...
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Downregulation of MicroRNA-495 Alleviates IL-1β Responses among Chondrocytes by Preventing SOX9 Reduction

Joung S, Yoon DS, Cho S, Ko EA, Lee KM, Park KH, Lee JW, Kim SH

Purpose: Our previous work demonstrated that miRNA-495 targets SOX9 to inhibit chondrogenesis of mesenchymal stem cells. In this study, we aimed to investigate whether miRNA-495-mediated SOX9 regulation could be a novel...
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Truncal Changes in Patients Suffering Severe Hip or Knee Osteoarthritis: A Surface Topography Study

Kechagias VA, Grivas TB, Papagelopoulos PJ, Kontogeorgakos VA, Vlasis K

Background: Osteoarthritis (OA) of the hip and knee is a degenerative disease with complications, including reduced range of motion and pain. Although OA of the hip and knee is common,...
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Accuracy of 2D CT-Based Measurements of Rotational Alignment of the Femoral Component for Total Knee Arthroplasty

Park JY, Kwon HM, Cho BW, Lee WS, Yang IH, Park KK

Purpose: We aimed to investigate the accuracy of two-dimensional computed tomography (2D-CT)-based methods for measuring rotational alignment of the femoral component during total knee arthroplasty in comparison to reference values...
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Hip Arthrodesis to Treat Severe Hip Osteoarthritis in an Adolescent with Down Syndrome

Jung YH, Shin KY, Lee JY

Down syndrome is the most common chromosomal disorder and is accompanied by hip osteoarthritis in approximately 28% of patients. This paper reports a case of hip arthrodesis as a treatment for...
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The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study

Lee YH, Song GG

Objective: The aim of this study was to examine if the intestinal microbiome is causally correlated with osteoarthritis (OA) incidence. Methods: A two-sample Mendelian randomization (MR) study was conducted using...
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Computed Tomography-Based Morphologic Analysis of Osteoarthritis of the Distal Radioulnar Joint Associated with Extensor Tendon Ruptures

Jang MG, Heo YM, Min YK, Kim TG, Oh BH, Kim TH

Background: Although the scallop sign is considered the most important risk factor for extensor tendon ruptures (ETRs) in patients with osteoarthritis of the distal radioulnar joint (DRUJ), previous reports provide...
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Relationship of Bone Mineral Density and Knee Osteoarthritis (Kellgren-Lawrence Grade): Fifth Korea National Health and Nutrition Examination Survey

Choi ES, Shin HD, Sim JA, Na YG, Choi WJ, Shin DD, Baik JM

Background: Osteoarthritis (OA) and osteoporosis (OP) are the 2 most common bone disorders associated with aging. We can simply assume that older patients have a higher incidence of OA and...
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Clinical Results of Medial Unicompartmental Knee Arthroplasty in Elderly Patients Older than 70 Years of Age

Kim KT, Lee S, Kim JH, Lee HY, Kim MJ

Purpose: To evaluate the long-term clinical results and survivorship of unicompartmental knee arthroplasty (UKA) in elderly patients older than 70 years by analyzing cases that have been implanted for >10...
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Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment

Mou D, Yu Q, Zhang J, Zhou J, Li X, Zhuang W, Yang X

BACKGROUND: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the...
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Ultrasound Findings were Associated With Radiographic Changes, But Not Clinical and Functional Outcomes in Hand Osteoarthritis

Kim SK, Jung UH, Kim JW, Choe JY

Objective. There is a debate over the relevance of ultrasound abnormalities to the pain, functional impairment, and radiologic severity in hand osteoarthritis (OA). This study aims to determine the association...
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Appropriateness of the Use of Navigation System in Total Knee Arthroplasty

Jung SH, Cho MR, Song SK

Background: The aim of this study was to evaluate the difference between the planned and verified actual values in total knee arthroplasty (TKA) performed using a navigation system. Methods: Sixty patients...
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Does Knee Arthroscopy for Treatment of Meniscal Damage with Osteoarthritis Delay Knee Replacement Compared to Physical Therapy Alone?

Navarro RA, Adams AL, Lin CC, Fleming J, Garcia IA, Lee J, Black MH

Background: To determine patient factors that lead to treatment of meniscal tears with osteoarthritis (OA) with knee arthroscopy (KA) or physical therapy only (PT-only); and to assess differences in clinical...
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Incidental findings of temporomandibular joint osteoarthritis and its variability based on age and sex

Alzahrani A, Yadav S, Gandhi V, Lurie AG, Tadinada A

Purpose: This study investigated the prevalence of temporomandibular joint osteoarthritis (TMJ-OA) using the Research Diagnostic Criteria for Temporomandibular Disorders image analysis criteria, assessed the severity of incidental osteoarthritic changes affecting...
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The role of radiation treatment in the management of inflammatory musculoskeletal conditions: a revisit

Abdus-Salam AA, Olabumuyi AA, Jimoh MA, Folorunso SA, Orekoya AA

Inflammatory musculoskeletal conditions are a common group of diseases among the elderly, worldwide. They are characterized by articular degenerative changes accompanied with often debilitating pain. Treatments often involve life-long analgesic...
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A Structural Equation Model of Health-Related Quality of Life among Older Women Following Bilateral Total Knee Replacement

Lee HO, Yoo JS

Purpose: This study aimed to develop and test a structural equation model of health-related quality of life among older women following bilateral total knee replacement based on a literature review...
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Current state of total knee arthroplasty

Seo JH, Lee SH

Total knee arthroplasty (TKA) is a successful and cost-effective treatment for end-stage degenerative arthritis. The aging of society and an increase in the prevalence of obesity has led to increases...
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Relationship between Knee Osteoarthritis and Spinopelvic Sagittal Alignment in Volunteers over 50 Years of Age

Yasuda T, Togawa D, Hasegawa T, Yamato Y, Kobayashi S, Yoshida G, Banno T, Arima H, Oe S, Hoshino H, Koyama H, Hanada M, Imada T, Matsuyama Y

Study Design: Large cohort study of volunteers. Purpose: The purpose of this study was to investigate the relationship between the severity of knee osteoarthritis, assessed using the Kellgren-Lawrence (KL) grading scale,...
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Comparing the effectiveness of ultrasound guided versus blind genicular nerve block on pain, muscle strength with isokinetic device, physical function and quality of life in chronic knee osteoarthritis: a prospective randomized controlled study

Cankurtaran D, Karaahmet OZ, Yildiz SY, Eksioglu E, Dulgeroglu D, Unlu E

Background: The genicular nerve block (GNB) is demonstrated from several reports to alleviate pain and improve knee functionality in patients with chronic knee osteoarthritis (OA). Ultrasound (US)-guided GNB has been...
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