Korean J Obstet Gynecol.  1998 Jan;41(1):228-235.

The Changes of SOD, Catalase and GPX in Alloxan Induced Diabetic Pregnant Rats, Their Feurses and Neonates

• Han SJ
• Hong KP
• Bae HY

Abstract

The activites of pulmonary antioxidant enzymes in alloxan-induced diabetic pregnant rats. their fetuses and neonates. The superoxide dismutase (SOD) and catalase activity were increased in diabetic nonpregnant female rats in comparison with normal control female rats. But the chagnes of antioxidant enzymes in lung of diabetic pregnant rats were not significant. In fetal lung of diabetic rats, the catalase activity decreased significantly, where as the changes of SOD and glutathione peroxidase (GPX) activity were not siginificant in compared with nondiabetic fetal lung. The SOD activities in lung of neonates from diabetic female decreased at day 1 and days 7. In lungs, the catatlase activities decreased significantly at day 1, days 7 and days 14 after birth. In these results decreased activities of catalase and SOD were more susceptible to oxidative lung injury, and these alterations of antioxidant enzymes may be a causative factors of respiratory distress in diabetic neonates.

Keyword

Diabetic rats; Alloxan; Superoxide dismutase ( SOD ); Catalase; Glutathione peroxidase ( GPX )

MeSH Terms

Alloxan*
Animals
Catalase*
Female
Fetus
Glutathione Peroxidase
Humans
Infant, Newborn*
Lung
Lung Injury
Parturition
Rats*
Superoxide Dismutase
Alloxan
Catalase
Glutathione Peroxidase
Superoxide Dismutase