Toxicol Res.  2013 Mar;29(1):15-19.

Antihyperglycemic and Antihyperlipidemic Effects of Fermented Rhynchosia nulubilis in Alloxan-induced Diabetic Rats

• Kim MJ
• Ha BJ

Abstract

Alloxan administration in rats is used as a model for non-insulin dependent diabetes mellitus (NIDDM). NIDDM is a multifactorial disease, characterized by hyperglycemia and lipoprotein abnormalities. In this study, we evaluated the antihyperglycemic and antihyperlipidemic effects of fermented Rhynchosia nulubilis (FRN) through the regulation of glucose uptake in alloxan-induced rats. Fermented R. nulubilis was administered orally for 28 d at 500 mg/kg of body weight. Body weight and food intake were monitored every day. Biochemical parameters were quantified after 4 week. In the diabetic + FRN group, body weight increased significantly and blood glucose concentrations decreased when compared to those of the diabetic group. After 2 hr of administration, the oral glucose tolerance test (OGTT) indicated a significant reduction in the diabetic + FRN group compared to diabetic group. The diabetic + FRN group experienced a significant reduction in total cholesterol, triglycerides, low density lipoprotein, coronary risk factors, and malondialdehyde concentrations, with significantly increased high density lipoprotein compared to those of diabetic group. These results demonstrate that fermented R. nulubilis possesses potent antihyperglycemic and antihyperlipidemic activity in alloxan-induced diabetic rats.

Keyword

Alloxan; Rhynchosia nulubilis; Hyperglycemic; Hyperlipidemic

MeSH Terms

Alloxan
Animals
Blood Glucose
Body Weight
Cholesterol
Diabetes Mellitus
Diabetes Mellitus, Type 2
Eating
Glucose
Glucose Tolerance Test
Hyperglycemia
Lipoproteins
Malondialdehyde
Rats
Risk Factors
Triglycerides
Alloxan
Blood Glucose
Cholesterol
Glucose
Lipoproteins
Malondialdehyde
Triglycerides