Mycobiology.  2012 Mar;40(1):20-26.

Synthesis of New VO(II), Co(II), Ni(II) and Cu(II) Complexes with Isatin-3-Chloro-4-Floroaniline and 2-Pyridinecarboxylidene-4-Aminoantipyrine and their Antimicrobial Studies

• Mishra AP
• Mishra R
• Jain R
• Gupta S

Abstract

The complexes of tailor made ligands with life essential metal ions may be an emerging area to answer the problems of multi drug resistance. The coordination complexes of VO(II), Co(II), Ni(II) and Cu(II) with the Schiff bases derived from isatin with 3-chloro-4-floroaniline and 2-pyridinecarboxaldehyde with 4-aminoantipyrine have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, molar conductance, electronic spectra, FT-IR, FAB mass and magnetic susceptibility measurements. FAB mass data show degradation of complexes. Both the ligands behave as bidentate and tridentate coordinating through O and N donor. The complexes exhibit coordination number 4, 5 or 6. The Schiff base and metal complexes show a good activity against the bacteria; Staphylococcus aureus, Escherichia coli and Streptococcus fecalis and fungi Aspergillus niger, Trichoderma polysporum, Candida albicans and Aspergillus flavus. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases. The minimum inhibitory concentrations of the metal complexes were found in the range 10~40 microg/mL.

Keyword

Isatin; MIC; Spectral studies; 2-Pyridinecarboxylidene; 4-Aminoantipyrine

MeSH Terms

Ampyrone
Anti-Infective Agents
Aspergillus flavus
Aspergillus niger
Candida albicans
Coordination Complexes
Drug Resistance
Electronics
Electrons
Escherichia coli
Fungi
Humans
Ions
Isatin
Ligands
Magnetics
Magnets
Microbial Sensitivity Tests
Microwaves
Molar
Pyridines
Schiff Bases
Staphylococcus aureus
Streptococcus
Tissue Donors
Trichoderma
Ampyrone
Anti-Infective Agents
Coordination Complexes
Ions
Isatin
Ligands
Pyridines
Schiff Bases