Mycobiology.  2009 Jun;37(2):141-146.

Antifungal Activities of Copper(II) with Biosensitive Macrocyclic Schiff Base Ligands Derived from 4-Aminoantipyrine Derivatives

• Gopalakrishnan S
• Joseph J

Abstract

Novel copper(II) complexes have been synthesized from the macrocyclic Schiff bases derived from Knoevenagel condensed beta-ketoanilides (obtained by the condensation of acetoacetanilide and substituted benzaldehydes), 4-aminoantipyrine and o-phenylene diamine. The structural features have been determined from their analytical and spectral data. All the Cu(II) complexes exhibit square planar geometry. Their high molar conductance values support their 1 : 2 electrolytic nature. The magnetic moment data provide evidence for the monomeric nature of the complexes. The X-band ESR spectra of the [CuL1](OAc)2 in DMSO solution at 300 and 77 K were recorded and their salient features are reported. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by well diffusion method. A comparative study of inhibition values of the Schiff bases and their complexes indicate that complexes exhibit higher antimicrobial activity than the Schiff bases. Copper ions proved to be essential for the growth-inhibitor effect. The extent of inhibition appeared to be strongly dependent on the initial cell density and on the growth medium.

Keyword

Biological screening; Inhibition; Schiff bases; Well diffusion

MeSH Terms

Acetanilides
Ampyrone
Aspergillus flavus
Aspergillus niger
Candida albicans
Cell Count
Copper
Diffusion
Dimethyl Sulfoxide
Escherichia coli
Ions
Klebsiella pneumoniae
Ligands
Magnetics
Magnets
Mass Screening
Molar
Proteus vulgaris
Pseudomonas aeruginosa
Rhizoctonia
Rhizopus
Schiff Bases
Staphylococcus aureus
Acetanilides
Ampyrone
Copper
Dimethyl Sulfoxide
Ions
Ligands
Schiff Bases