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Tolfenamic Acid Inhibits the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma: Involvement of p38-Mediated Down-Regulation of Slug

Jittreetat T, Shin YS, Hwang HS, Lee BS, Kim YS, Sannikorn , Kim CH

PURPOSE: Tolfenamic acid (TA), a non-steroidal anti-inflammatory drug, is known to exhibit antitumor effects in various cancers apart from nasopharyngeal cancer (NPC). NPC exhibits high invasiveness, as well as metastatic...
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Effect of a Sleep Aid in Analgesia after Arthroscopic Rotator Cuff Repair

Cho CH, Lee SW, Lee YK, Shin HK, Hwang I

PURPOSE: The aim of this study was to evaluate the effects and safety of a sleep aid for postoperative analgesia in patients undergoing arthroscopic rotator cuff repair. MATERIALS AND METHODS: Seventy-eight...
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beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells

Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I

An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene....
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Anatomic Conformity of New Periarticular Locking Plates for Koreans: A Biomechanical Cadaveric Study

Yoon YC, Oh JK, Kim YW, Kim HJ, Moon HJ, Kim NR

  • KMID: 2297793
  • J Korean Soc Traumatol.
  • 2013 Sep;26(3):163-169.
PURPOSE: This study was conducted to confirm the anatomic conformity of the new periarticular locking plates designed by Zimmer on Korean adult bones and to identify the structures at risk...
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Self-monitoring Glucometers: How Accurate Are They?

Na Y

Glucometers offer a simple and rapid method of self-monitoring blood glucose levels and are widely used by diabetic clinics and patients. The accuracy of a glucometer depends on the meter's...
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Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells

Youn CK, Park SJ, Li MH, Lee MY, Lee KY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ

Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine...
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Psychopharmacotherapy for Pregnant Women

Jeong JH, Suh HS, Lim W, Lee SY

  • KMID: 2287502
  • Korean J Psychopharmacol.
  • 2013 Jul;24(3):102-114.
Authors reviewed the risk of psychopharmacotherapies during pregnancy. Psychopharmaotherapy in pregnants should be determined by considering the risk of disease recurrence in the mother and the impacts on the fetus....
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New Oral Antiplatelet Agents

Kang MK, Chang K

  • KMID: 2267821
  • Korean J Med.
  • 2013 Jul;85(1):10-14.
Antiplatelet agents play an essential role in the treatment of acute coronary syndrome (ACS). Aspirin and thienopyridines comprise the major classes of antiplatelet therapies demonstrated to be of benefit in...
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The Chicken Aorta as a Simulation-Training Model for Microvascular Surgery Training

Ramachandran S, Chui CH, Tan BK

As a technically demanding skill, microsurgery is taught in the lab, in the form of a course of variable length (depending on the centre). Microsurgical training courses usually use a...
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In Vitro Evaluation of Antimicrobial Activity of Lactic Acid Bacteria against Clostridium difficile

Lee JS, Chung MJ, Seo JG

  • KMID: 2317822
  • Toxicol Res.
  • 2013 Jun;29(2):99-106.
Clostridium difficile infection (CDI) has become a significant threat to public health. Although broad-spectrum antibiotic therapy is the primary treatment option for CDI, its use has evident limitations. Probiotics have...
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Incidence of and Risk Ractors for Zolpidem-Induced Delirium

Kim YM, Lee S, Jung JY, Shin KH, Kim DH, Kim JH, Jee YK

  • KMID: 2142894
  • Korean J Med.
  • 2013 Jun;84(6):804-809.
BACKGROUND/AIMS: Zolpidem is a safe and effective drug for the treatment of insomnia. However, there are some reports of adverse effects, such as delirium, after administration of zolpidem. The aim...
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Zolpidem, Is it a Safe Drug for Insomnia Management?

Park KH, Lee JH

  • KMID: 2142893
  • Korean J Med.
  • 2013 Jun;84(6):802-803.
Zolpidem is one of commonly prescribed hypnotics in worldwide. Zolpidem is more favored than benzodiazepines because of its efficacy and safety profiles. However there were many reports those concerns about...
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The effect of acrylamide incorporation on the thermal and physical properties of denture resins

Aydogan Ayaz E, Durkan R, Bagis B

PURPOSE: Polymethyl methacrylate (PMMA) is the most commonly used denture base material despite typically low in strength. The purpose of this study was to improve the physical properties of the...
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In Vitro Effects of SB202190 on Echinococcus granulosus

Lv H, Li S, Zhang J, Liang W, Mu X, Jiang Y

Spillage of cyst contents during surgical operation is the major cause of recurrence after hydatid cyst surgery. Instillation of a scolicidal agent into a hepatic hydatid cyst is the most...
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Signaling Pathway of Lysophosphatidic Acid-Induced Contraction in Feline Esophageal Smooth Muscle Cells

Nam YS, Suh JS, Song HJ, Sohn UD

Lysolipids such as LPA, S1P and SPC have diverse biological activities including cell proliferation, differentiation, and migration. We investigated signaling pathways of LPA-induced contraction in feline esophageal smooth muscle cells....
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Ginsenoside Rg2 Inhibits Lipopolysaccharide-Induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cell

Cho YS, Kim CH, Ha TS, Lee SJ, Ahn HY

Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant...
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Preliminary Study for a Multicenter Study of Alzheimer's Disease Cerebrospinal Fluid Biomarkers

Park SA, Kim JH, Kim HJ, Kim TE, Kim YJ, Lee DH, Park JH, Chae WS, Yim SJ, Seo SW, Na DL, Choi SH

BACKGROUND: The usefulness of cerebrospinal fluid (CSF) concentrations of amyloid beta protein 1-42 (Abeta42), phosphorylated tau (pTau) and total tau (tTau) have been increasing in Alzheimer's disease (AD). However, the...
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Effect of ROCK Inhibitor on the Expansion and Wound Healing of Human Corneal Endothelial Cell

Kim KH, Chung JK, Ryu JS, Koh AY, Kim MK, Wee WR

PURPOSE: To investigate the effect of ROCK inhibitor Y27632 on the human corneal endothelial cell proliferation in vitro and in vivo. METHODS: Using corneal endothelial cells isolated and cultured from human...
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Influence of PD 123319 (AT2-Receptor Antagonist) on Catecholamine Secretion in the Perfused Rat Adrenal Medulla

Hong SP, Bidur B, Choi MS, Seo YH, Lim DY

BACKGROUND: The aim of this study was to examine whether PD 123319 (an angiotensin II type 2 [AT2] receptor antagonist) can influence the release of catecholamines (CA) from the perfused...
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Safety Evaluation of Stamp Type Digital Microneedle Devices in Hairless Mice

Park KY, Jang WS, Lim YY, Ahn JH, Lee SJ, Kim CW, Kim SE, Kim BJ, Kim MN

BACKGROUND: Microneedles provide a minimally invasive means to transport molecules into the skin. A number of specific strategies have been employed to use microneedles for transdermal delivery. OBJECTIVE: The purpose of...
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