- A general view of CD33⺠leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy
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Fathi E, Farahzadi , Sheervalilou R, Sanaat Z, Vietor I
- KMID: 2472003
- Blood Res.
- 2020 Mar;55(1):10-16.
- doi: 10.5045/br.2020.55.1.10
Acute myeloblastic leukemia (AML) is the most frequent acute leukemia in adulthood with very poor overall survival rates. In the past few decades, significant progresses had led to the findings... -
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- Role of Efflux Pump Gene adeIJK to Multidrug Resistance in Acinetobacter baumannii Clinical Isolates
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Choi JA, Kim CM, Jang SJ, Cho SS, Jang CH, Ko YJ, Kang SH, Park G
- KMID: 2471858
- Ann Clin Microbiol.
- 2020 Mar;23(1):45-54.
- doi: 10.5145/ACM.2020.23.1.45
BACKGROUND: The emergence of multidrug-resistant Acinetobacter baumannii as a nosocomial pathogen is one of the major public health problems. The aim of this study was to evaluate the role of... -
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- Evaluation of Synergistic Effect of Combined Treatment with Linalool and Colistin on Multidrug-Resistant Acinetobacter baumannii to Expand Candidate for Therapeutic Option
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Kim UJ, Kim CM, Jang SJ, Lee SB, Cho SS, Jeong SH, Ko YJ, Kang SH, Park G, Kim DM, Yoon NR, Ahn YJ, Lim DH, Kook JK
- KMID: 2471855
- Ann Clin Microbiol.
- 2020 Mar;23(1):11-20.
- doi: 10.5145/ACM.2020.23.1.11
BACKGROUND: Acinetobacter baumannii infection is a significant health problem worldwide due to increased drug resistance. The limited antimicrobial alternatives for the treatment of severe infections by multidrug-resistant A. baumannii (MDRAB)... -
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- Evaluation of the QuantaMatrix Multiplexed Assay Platform for Molecular Diagnosis of Multidrug- and Extensively Drug-Resistant Tuberculosis Using Clinical Strains Isolated in Myanmar
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Chang Y, Kim S, Kim Y, Ei PW, Hwang D, Lee J, Chang CL, Lee H
- KMID: 2460911
- Ann Lab Med.
- 2020 Mar;40(2):142-147.
- doi: 10.3343/alm.2020.40.2.142
BACKGROUND: Although the incidence of tuberculosis (TB) is decreasing, cases of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB continue to increase. As conventional phenotype drug susceptibility testing (pDST) takes... -
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- Prescription of antibiotics after tooth extraction in adults: a nationwide study in Korea
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Choi YY
- KMID: 2471112
- J Korean Assoc Oral Maxillofac Surg.
- 2020 Feb;46(1):49-57.
- doi: 10.5125/jkaoms.2020.46.1.49
OBJECTIVES: This study aimed to understand the nationwide patterns of antibiotic prescription after tooth extraction in adult patients. MATERIALS AND METHODS: This study analyzed dental records from the National Health Insurance... -
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- Comparison of 7- and 14-Day Eradication Therapy for Helicobacter pylori with First- and Second-Line Regimen: Randomized Clinical Trial
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Kim TH, Park JM, Cheung DY, Oh JH
- KMID: 2469349
- J Korean Med Sci.
- 2020 Feb;35(5):e33.
- doi: 10.3346/jkms.2020.35.e33
BACKGROUND: Although Helicobacter pylori is a key cause of gastric cancer development, its eradication rate has been decreasing by standard regimens. For successful eradication, duration of treatment has been issued... -
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- Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma
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Hwang HS, Park YY, Shin SJ, Go H, Park JM, Yoon SY, Lee JL, Cho YM
- KMID: 2469348
- J Korean Med Sci.
- 2020 Feb;35(5):e31.
- doi: 10.3346/jkms.2020.35.e31
BACKGROUND: Mechanism and predictive biomarkers for tyrosine kinase inhibitor (TKI) resistance of advanced clear cell renal cell carcinoma (ccRCC) have not been fully evaluated. METHODS: We performed gene expression profiling on... -
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- Livestock-associated methicillin-resistant Staphylococcus aureus in Korea: antimicrobial resistance and molecular characteristics of LA-MRSA strains isolated from pigs, pig farmers, and farm environment
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Back SH, Eom HS, Lee HH, Lee GY, Park KT, Yang SJ
- KMID: 2469017
- J Vet Sci.
- 2020 Jan;21(1):e2.
- doi: 10.4142/jvs.2020.21.e2
The emergence of livestock-associated (LA)-methicillin-resistant Staphylococcus aureus (MRSA) in livestock animal has become a significant zoonotic concern. In the present study, we investigated nationwide prevalence of LA-MRSA across pork production... -
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- Eradication Therapy for Helicobacter pylori with Diagnostic Test for Clarithromycin Resistance
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Kim YJ, Chung WC
- KMID: 2469313
- Korean J Helicobacter Up Gastrointest Res.
- 2019 Dec;19(4):225-230.
- doi: 10.7704/kjhugr.2019.0019
Addressing the increasing antibiotic resistance, including clarithromycin resistance, which affects Helicobacter pylori (H. pylori) eradication therapy, is a challenge for clinicians. Antibiotic resistance is the main reason for H. pylori... -
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- High-quality draft genome and characterization of commercially potent probiotic Lactobacillus strains
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Sulthana A, Lakshmi SG, Madempudi
- KMID: 2468869
- Genomics Inform.
- 2019 Dec;17(4):e43.
- doi: 10.5808/GI.2019.17.4.e43
Lactobacillus acidophilus UBLA-34, L. paracasei UBLPC-35, L. plantarum UBLP-40, and L. reuteri UBLRU-87 were isolated from different varieties of fermented foods. To determine the probiotic safety at the strain level,... -
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- Overcoming the Intrinsic Gefitinib-resistance via Downregulation of AXL in Non-small Cell Lung Cancer
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Jeong I, Song J, Bae SY, Lee SK
- KMID: 2468811
- J Cancer Prev.
- 2019 Dec;24(4):217-223.
- doi: 10.15430/JCP.2019.24.4.217
BACKGROUND: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. Therefore, ongoing studies... -
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- p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
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Jin Y, Heo KS
- KMID: 2468028
- J Bacteriol Virol.
- 2019 Dec;49(4):221-229.
- doi: 10.4167/jbv.2019.49.4.221
p90 ribosomal S6 kinase (p90RSK), one of the downstream effectors in ERK1/2 pathways, shows high expression in human breast cancer tissues. However, its role in breast cancer development and drug... -
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- Colonization Prevalence and Risk Factor Analysis of Carbapenem-Resistant Acinetobacter baumannii in an Intensive Care Unit without Outbreaks
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Kim YA, Park YS, Lee SS, Son YJ, Yeon JH, Seo YH, Lee K
- KMID: 2467907
- Korean J healthc assoc Infect Control Prev.
- 2019 Dec;24(2):81-87.
- doi: 10.14192/kjicp.2019.24.2.81
BACKGROUND: Acinetobacter baumannii is a well-known etiologic agent of a variety of nosocomial infections; the resistance rate to imipenem is surprisingly high in Korea. The colonization of carbapenem-resistant A. baumannii... -
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- Antibiotic sensitivity and resistance of bacteria from odontogenic maxillofacial abscesses
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Kang SH, Kim MK
- KMID: 2467184
- J Korean Assoc Oral Maxillofac Surg.
- 2019 Dec;45(6):324-331.
- doi: 10.5125/jkaoms.2019.45.6.324
OBJECTIVES: This study investigated the types and antibiotic sensitivity of bacteria in odontogenic abscesses. MATERIALS AND METHODS: Pus specimens from 1,772 patients were collected from affected areas during incision and drainage,... -
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- Molecular Epidemiologic Study of a Methicillin-resistant Staphylococcus aureus Outbreak at a Newborn Nursery and Neonatal Intensive Care Unit
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Kang HM, Park KC, Lee KY, Park J, Park SH, Lee DG, Kim JH
- KMID: 2466459
- Pediatr Infect Vaccine.
- 2019 Dec;26(3):148-160.
- doi: 10.14776/piv.2019.26.e23
PURPOSE: This study aimed to investigate the molecular epidemiology of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak at a newborn nursery and neonatal intensive care unit (NICU). METHODS: During the outbreak, from... -
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- Molecular Epidemiology of Staphylococcus aureus in Skin and Soft Tissue Infections and Bone and Joint Infections in Korean Children
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Park SG, Lee HS, Park JY, Lee H
- KMID: 2466008
- J Korean Med Sci.
- 2019 Dec;34(49):e315.
- doi: 10.3346/jkms.2019.34.e315
BACKGROUND: Community acquired-methicillin resistant Staphylococcus aureus (MRSA) clones, including ST1, ST8, and ST30 are reported worldwide. However, data among Korean children are limited. Thus, we investigated the molecular characteristics of... -
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- Optimal antimicrobial therapy and antimicrobial stewardship in sepsis and septic shock
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Seok H, Park DW
- KMID: 2465358
- J Korean Med Assoc.
- 2019 Dec;62(12):638-644.
- doi: 10.5124/jkma.2019.62.12.638
The management of sepsis and septic shock remains challenging. The aim is to apply the optimal antimicrobial therapy and antimicrobial stewardship to patients in state of sepsis or septic shock.... -
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- Characteristic profiles of biofilm, enterotoxins and virulence of Staphylococcus aureus isolates from dairy cows in Xinjiang Province, China
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Wu Y, Li J, Qiao M, Meng D, Meng Q, Qiao J, Zhang X, Wang L, Cai K, Zhang J, Zhang Z, Yu W, Cai X
- KMID: 2464089
- J Vet Sci.
- 2019 Nov;20(6):e74.
- doi: 10.4142/jvs.2019.20.e74
As an important zoonotic pathogen, Staphylococcus aureus has led to serious mastitis and endometritis in infected dairy cows. In this study, a total of 164 strains of S. aureus were... -
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- Prevalence and characteristics of livestock-associated methicillin-susceptible Staphylococcus aureus in the pork production chain in Korea
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Eom HS, Back SH, Lee HH, Lee GY, Yang SJ
- KMID: 2464085
- J Vet Sci.
- 2019 Nov;20(6):e69.
- doi: 10.4142/jvs.2019.20.e69
The emergence and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) in livestock animals have become a worldwide public health concern. While the prevalence and genetic profiles... -
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- FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a Oâ¶-methylguanine-DNA methyltransferase-dependent manner
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Shangguan , Lv X, Tian N
- KMID: 2461040
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):475-482.
- doi: 10.4196/kjpp.2019.23.6.475
Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma... -
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