Ewha Med J.  2018 Jan;41(1):8-12. 10.12771/emj.2018.41.1.8.

Changes in Serum Concentrations of Insulin-like Growth Factor Binding Protein-3 after General Anesthesia Using Propofol or Isoflurane

• Woo JH
• Kim JH
• Baik HJ
• Lee M
• Kim YJ

• KMID: 2403017
• DOI: http://doi.org/10.12771/emj.2018.41.1.8

Abstract

OBJECTIVES
The insulin-like growth factor binding proteins (IGFBP) regulate the bioavailability and bioactivity of insulin-like growth factor. We aimed to evaluate whether the IGFBP-3 level undergo major changes during perioperative periods according to the different kind of anesthetic agents.
METHODS
Eighteen adults scheduled for elective total abdominal hysterectomy were enrolled. The patients were randomly assigned to have either propofol or isoflurane for maintenance of general anesthesia. A venous sample was taken for analysis of IGFBP-3 at the following time points: before induction, at the time of peritoneal closure, 1 hour after extubation at recovery room, and 2 and 5 postoperative days. The samples were analyzed by enzyme linked immunosolvent assay.
RESULTS
Demographic data were similar between groups. In the both groups, the IGFBP-3 concentration decreased after anesthesia induction, reaching a nadir at the time of peritoneal closure without a significant difference between groups. In analysis between groups, the IGFBP-3 concentration in the isoflurane group on the postoperative 5th day was recovered to preoperative value and significantly higher than that in the propofol group (P < 0.05).
CONCLUSION
This is the first study to show that the anesthetics used for general anesthesia affect the IGFBP-3 level during perioperative periods. The decrease of IGFBP-3 level following anesthesia induction in the isoflurane group was recovered to preoperative value, whereas that observed in the propofol group was not recovered on the postoperative 5th day. Further study is needed to establish the definitive effect of general anesthetics on IGFBP-3 and provide a comprehensive interpretation.

Keyword

Anesthesia, general; Insulin-like growth factor binding protein 3; Isoflurane; Propofol

MeSH Terms

Adult
Anesthesia
Anesthesia, General*
Anesthetics
Anesthetics, General
Biological Availability
Humans
Hysterectomy
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
Isoflurane*
Perioperative Period
Propofol*
Recovery Room
Anesthetics
Anesthetics, General
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
Isoflurane
Propofol

Figure

• 

  Fig. 1 The changes in serum insulin-like growth factor binding protein (IGFBP)-3 concentrations in propofol and isoflurane group before induction, at the closure of peritoneum, 1 hour, 2 and 5 days following surgery. The IGFBP-3 concentration did not change significantly throughout the study period within each group, however, there was a significant difference of the IGFBP-3 concentration on the postoperative 5th day between groups. POD, postoperative day. *P<0.05 compared between groups.

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