- Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice
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Prasad S, Tyagi AK, Aggarwal B
- KMID: 2167649
- Cancer Res Treat.
- 2014 Jan;46(1):2-18.
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000... -
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- Assessment of the Intake and Availability of Dietary Iron and Nutrition Knowledge in Pregnant Women
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Kim E, Lee K
- KMID: 2300847
- Korean J Community Nutr.
- 1998 Feb;3(1):53-61.
This study was designed to estimate mean daily iron intake and its bioavailability and to assess nutrition knowledge for 144 pregnant women in the last trimester. Serum ferritin concentration was... -
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- Biological roles of insulin-like growth factor binding proteins (IGFBPs)
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Kim HS, Rosenfeld , Oh YM
- KMID: 2045603
- Exp Mol Med.
- 1997 Jun;29(2):85-96.
The insulin-like growth factor binding protein (IGFBP) family is a critical component of the insulin-like growth factor (IGF) system which regulate the biological actions of the IGFs and may also... -
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- Effects of Nitric Oxide Donor Supplementation on Copper Deficient Embryos and Nitric Oxide-Mediated Downstream Signaling
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Yang SJ
- KMID: 2263209
- Korean J Nutr.
- 2008 Dec;41(8):691-700.
One suggested mechanism underlying copper (Cu) deficiency teratogenicity is a low availability of nitric oxide (NO), a signaling molecule which is essential in developmental processes. Increased superoxide anions secondary to... -
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- Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin
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Park MY, Kwon HJ, Sung MK
- KMID: 2313344
- Nutr Res Pract.
- 2008 Mar;2(1):17-21.
Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this... -
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- Comparative Study of First-in-Human Dose Estimation Approaches using Pharmacometrics
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Baek IH
- KMID: 2358067
- Korean J Clin Pharm.
- 2016 Jun;26(2):150-162.
- doi: 10.0000/kjcp.2016.26.2.150
OBJECTIVE: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. METHODS: First-in-human... -
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- Direct-acting antivirals response in hepatocellular carcinoma: Does the presence of hepatocellular carcinoma matter?
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Huang CF, Yu ML
- KMID: 2451919
- Clin Mol Hepatol.
- 2019 Jun;25(2):168-171.
- doi: 10.3350/cmh.2018.1014
During the clinical trial development of directly acting antivirals (DAAs), evidence regarding the treatment efficacy in chronic hepatitis C patients with hepatocellular carcinoma (HCC) was scarce because these patients have... -
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- The stable isotope method for determining absolute bioavailability
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Atkinson A
- KMID: 2386760
- Transl Clin Pharmacol.
- 2017 Jun;25(2):53-58.
- doi: 10.12793/tcp.2017.25.2.53
The bioavailability of a drug is usually assessed in healthy subjects. However, it is reasonable to expect that significant alterations in bioavailability may occur in actual patients with different diseases... -
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- Psychotropics Metabolism: Gender-Related Issues
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Hong HJ, Kim CH
- KMID: 2287306
- Korean J Psychopharmacol.
- 2003 Dec;14(4):330-335.
There are significant gender differences in pharmacokinetics and pharmacodynamics of psychotropic medications. Gender differences in pharmacokinetics such as drug absorption, bioavailability, drug distribution, drug metabolism, and elimination have clinical implications... -
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- Human Exposure and Health Effects of Inorganic and Elemental Mercury
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Park JD, Zheng W
- KMID: 1499656
- J Prev Med Public Health.
- 2012 Nov;45(6):344-352.
Mercury is a toxic and non-essential metal in the human body. Mercury is ubiquitously distributed in the environment, present in natural products, and exists extensively in items encountered in daily... -
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- Microbiome-Linked Crosstalk in the Gastrointestinal Exposome towards Host Health and Disease
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Moon Y
- KMID: 2364762
- Pediatr Gastroenterol Hepatol Nutr.
- 2016 Dec;19(4):221-228.
- doi: 10.5223/pghn.2016.19.4.221
The gastrointestinal exposome represents the integration of all xenobiotic components and host-derived endogenous components affecting the host health, disease progression and ultimately clinical outcomes during the lifespan. The human gut... -
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- Effect of Dietary Supplementation of Sypjeondaebotang or Jahyulyanggeuntang on Iron Bioavailability in Rats
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Yang MZ, Kim YJ, Park T
- KMID: 2269650
- Korean J Nutr.
- 2003 Apr;36(3):262-269.
The effect of dietary supplementation of the two oriental medicinal prescriptions, Sypjeondaebotang or Jahyulyanggeuntang, on iron bioavailability was evaluated in rats which were depleted of iron by being fed an... -
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- Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
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Kim KY, An YM, Kim TW, Jun YH, Lee JE, Jang JH, Kim SK
- KMID: 2358362
- Clin Pediatr Hematol Oncol.
- 2016 Oct;23(2):77-82.
- doi: 10.15264/cpho.2016.23.2.77
BACKGROUND: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food... -
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- Comparative Bioavailability and Efficasy of Tobra(R) or Tobrex(R)
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Kim EK, Kim HB, Kim SY
- KMID: 1949286
- J Korean Ophthalmol Soc.
- 1989 Apr;30(2):175-180.
Two topical 0.3% tobramycin ophthalmic solutions, Tobra(R) and Tobrex(R) were tested for their effects on external eyes in rabbits. The authors studied irritation, epithelial toxicity, pH of solutions and antibiotic... -
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- Iron Nutritional Status of Female Students in Kangnung National University
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Lee K, Kim E, Kim M
- KMID: 2300908
- Korean J Community Nutr.
- 1997 Feb;2(1):23-32.
To evaluate iron nutritional status of female college students, fasting blood samples were taken from 76 female students of Kangnung National University. Hemoglobin(Hb), hematocrit(Hct), serum iron(Fe), total iron binding capacity(TIBC)... -
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- Formulation and Evaluation of Irinotecan Suppository for Rectal Administration
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Feng H, Zhu Y, Li D
- KMID: 2048335
- Biomol Ther.
- 2014 Jan;22(1):78-81.
Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using... -
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- Loop Diuretics in Clinical Practice
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Oh SW, Han SY
- KMID: 2052338
- Electrolyte Blood Press.
- 2015 Jun;13(1):17-21.
- doi: 10.5049/EBP.2015.13.1.17
Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are... -
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- A Study on Iron Nutritional Status of Girls at Puberty in Kangnung Area
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Kim EK, Ryu ON, Park KW
- KMID: 2300772
- Korean J Community Nutr.
- 1999 Jun;4(2):139-148.
This study was designed to assess the iron nutritional status of girls at puberty in Kangnung area. The subjects consisted of 161 adolescents in sixth-grade in primary school and first-grade... -
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- Revisiting the well-stirred model of hepatic clearance: Q(H), CL(H) and F changing in the same direction
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Yim DS
- KMID: 2351795
- Transl Clin Pharmacol.
- 2016 Sep;24(3):115-118.
- doi: 10.12793/tcp.2016.24.3.115
This tutorial examines the relationship between CL, F, and hepatic blood flow (Q(H)) quantitatively at oral and i.v. administration as an answer to the quiz set for KSCPT members. In... -
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- Rifampicin-Induced Severe Hyperkalemia Requiring Hemodialysis in a Patient with Addison's Disease
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Kim HG, Yoon YS, Kim HH, Kim YS, Kim BS, Yoon SA, Kim YO
- KMID: 2253205
- Korean J Nephrol.
- 2009 Jan;28(1):44-48.
Rifampicin, a potent inducer of hepatic microsomal enzymes, increases metabolism of steroid hormone. Therefore, concurrent treatment of rifampicin and steroid may lead to decreased bioavailability and increased requirement of steroid... -
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