Korean Circ J.  2017 Mar;47(2):151-159. 10.4070/kcj.2016.0207.

Adipose Tissue-Derived Stem Cells for Myocardial Regeneration

• Joo HJ
• Kim JH
• Hong SJ

• KMID: 2377451
• DOI: http://doi.org/10.4070/kcj.2016.0207

Abstract

Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility. In vitro studies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.

Keyword

Adipose tissue; Stem cell; Myocardium; Regeneration

MeSH Terms

Adipose Tissue
Animals
Heart Diseases
Humans
In Vitro Techniques
Myocardial Infarction
Myocardium
Myocytes, Cardiac
Regeneration*
Stem Cells*

Figure

• 

  Fig. 1 Effects of ADSCs on myocardial regeneration. ADSCs can be harvested readily, safely, and abundantly by liposuction. They can be cultured in vitro and differentiated into cardiomyocytes and other mesenchymal cells through direct transdifferentiation or cell-fusion. When transplanted into the infarcted myocardium by IC infusion or IM injection, ADSCs might contribute towards improvement in cardiac function. The suggested mechanisms include their paracrine effects modulating inflammatory response and inducing neoangiogenesis under hypoxic stress. ADSCs: adipose tissue-derived stem cells, IC: intracoronary, IM: intramuscular.

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