Korean J Biol Psychiatry.  2017 Feb;24(1):32-38. 10.0000/kjbp.2017.24.1.32.

The Relationship between the Amisulpride-Induced Hyperprolactinemia and Taq1A Polymorphism of the Dopamine D2 Receptor Gene in Schizophrenia Patients

• Kim JJ
• Seo MJ
• Choi TY
• Lee JH

• KMID: 2371181
• DOI: http://doi.org/10.0000/kjbp.2017.24.1.32

Abstract

OBJECTIVES
This study was aimed to investigate the association between amisulpride-induced hyperprolactinemia and the Taq1A polymorphism in the D2 dopamine receptor gene (DRD2) in schizophrenic patients.
METHODS
The plasma concentrations of prolactin were measured before and after treatment with amisulpride in one hundred and twenty-five schizophrenic patients. The effect of the Taq1A variants of the DRD2 on the risk of amisulpride-induced hyperprolac-tinemia was the main the outcome measure. The genotyping for Taq1A (rs1800497) polymorphism was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay.
RESULTS
There was a significant difference between the prolactin level at baseline and the 6th week after treatment with amisulpride in all the subjects. However, there were no significant correlations between ΔProlactin (the difference between prolactin level at baseline and the 6th week after treatment) and the Taq1A genotypes.
CONCLUSIONS
This is the first study to investigate the-correlations between the Taq1A polymorphism and the amisulpride-induced hyperprolactinemia in Korean schizophrenic patients. The current results suggested the further large-scale researches on various SNPs in the DRD2 gene will establish clear goals and provide answers to the unanswered questions described in this study.

Keyword

Amisulpride; DRD2 gene; Polymorphisms; Hyperprolactinemia

MeSH Terms

Dopamine*
Genotype
Humans
Hyperprolactinemia*
Outcome Assessment (Health Care)
Plasma
Polymorphism, Single Nucleotide
Prolactin
Receptors, Dopamine
Receptors, Dopamine D2*
Schizophrenia*
Dopamine
Prolactin
Receptors, Dopamine
Receptors, Dopamine D2