Gut Liver.
2016 Mar;10(2):250-254. 10.5009/gnl14435.
Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication
- Affiliations
-
- 1Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea. kchuh2020@hanmail.net
- 2Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
- 3Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
- 4Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 5Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
- 6Department of Internal Medicine, Eulji University Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
- 7Department of Internal Medicine, Chungnam National University Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
- 8Department of Internal Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon, Korea.
- KMID: 2363970
- DOI: http://doi.org/10.5009/gnl14435
Abstract
- BACKGROUND/AIMS
To determine the incidence and clinical characteristics of tuberculosis (TB) medication-associated Clostridium difficile infection.
METHODS
This multicenter study included patients from eight tertiary hospitals enrolled from 2008 to 2013. A retrospective analysis was conducted to identify the clinical features of C. difficile infection in patients who received TB medication.
RESULTS
C. difficile infection developed in 54 of the 19,080 patients prescribed TB medication, representing a total incidence of infection of 2.83 cases per 1,000 adults. Fifty-one of the 54 patients (94.4%) were treated with rifampin. The patients were usually treated with oral metronidazole, which produced improvement in 47 of the 54 patients (87%). Twenty-three patients clinically improved with continuous rifampin therapy for C. difficile infection. There were no significant differences in improvement between patients treated continuously (n=21) and patients in whom treatment was discontinued (n=26).
CONCLUSIONS
The incidence of C. difficile infection after TB medication was not low considering the relatively low TB medication dosage compared to other antibiotics. It may not be always necessary to discontinue TB medication. Instead, decisions concerning discontinuation of TB medication should be based on TB status.
MeSH Terms
-
Adult
Aged
Aged, 80 and over
Anti-Infective Agents/therapeutic use
Antibiotics, Antitubercular/*adverse effects
*Clostridium difficile
Enterocolitis, Pseudomembranous/chemically induced/drug therapy/*epidemiology
Female
Humans
Incidence
Male
Metronidazole/therapeutic use
Middle Aged
Retrospective Studies
Rifampin/*adverse effects
Treatment Outcome
Tuberculosis/*drug therapy
Anti-Infective Agents
Antibiotics, Antitubercular
Metronidazole
Rifampin
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