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Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations

Choi R, Jeong BH, Koh WJ, Lee SY

Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the...
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A Case of Paradoxical Reaction Development during Antituberculosis Therapy

Cho YB, Chu MS, Ryu HS, Choi SC, Seo GS

Paradoxical reaction during antituberculosis therapy is defined as aggravation of preexisting tuberculous lesions or the development of new lesions. A 24-year-old female college student diagnosed with abdominal and pulmonary tuberculosis...
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Retrospective Comparison of Levofloxacin and Moxifloxacin on Multidrug-Resistant Tuberculosis Treatment Outcomes

Lee J, Lee CH, Kim DK, Yoon HI, Kim JY, Lee SM, Yang SC, Lee JH, Yoo CG, Lee CT, Chung HS, Kim YW, Han SK, Yim JJ

BACKGROUND/AIMS: To compare the effect of levofloxacin and moxifloxacin on treatment outcomes among patients with multidrug-resistant tuberculosis (MDR-TB). METHODS: A retrospective analysis of 171 patients with MDR-TB receiving either levofloxacin or...
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Treatment Response and Adverse Reactions in Older Tuberculosis Patients with Immunocompromising Comorbidities

Kim SY, Lee SM, Yim JJ, Yoo CG, Kim YW, Han SK, Yang SC

PURPOSE: The aim of this study was to elucidate the effects of immunocompromising comorbidities on treatment response and adverse reactions in older tuberculosis (TB) patients. MATERIALS AND METHODS: The medical records...
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Clinical Outcomes of Tuberculosis in Renal Transplant Recipients

Park YS, Choi JY, Cho CH, Chang KH, Song YG, Kim YS, Kim JM

Tuberculosis (TB) is an important cause of morbidity and mortality in renal transplant recipients. Rifampin has a potent sterilizing activity, but it reduces the serum concentrations of the immunosuppressive agents....
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Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication

Lee YM, Huh KC, Yoon SM, Jang BI, Shin JE, Koo HS, Jung Y, Kim SH, Moon HS, Lee SW, Daejeon-Chungchung Intestinal Research Group

BACKGROUND/AIMS: To determine the incidence and clinical characteristics of tuberculosis (TB) medication-associated Clostridium difficile infection. METHODS: This multicenter study included patients from eight tertiary hospitals enrolled from 2008 to 2013. A...
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Predictors of Default from Treatment for Tuberculosis: a Single Center Case-Control Study in Korea

Park CK, Shin HJ, Kim YI, Lim SC, Yoon JS, Kim YS, Kim JC, Kwon YS

Default from tuberculosis (TB) treatment could exacerbate the disease and result in the emergence of drug resistance. This study identified the risk factors for default from TB treatment in Korea....
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