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Rifampin-Induced Immune Hemolytic Anemia during Treatment of Pulmonary Tuberculosis in a Patient with Primary Sjogren's Syndrome

Souk JW, Kim YK, Jang GE, Jeong HS, Uh ST, Kim KU, Koo SM, Lee BY, Noh H, Shin WY, Shin JW, Jin SY

Drug-induced immune hemolytic anemia is a rare disease that occurs in 1 in 1 million individuals of the general population. Rifampin-induced immune hemolytic anemia is caused by drug-dependent antibodies and...
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Screening and Treatment of Latent Tuberculosis Infection among Healthcare Workers at a Referral Hospital in Korea

Park SY, Lee E, Lee EJ, Kim TH, Kim YK

BACKGROUND: Healthcare workers (HCWs) have a high risk of tuberculosis (TB) infection. Since August 2017, Korea has mandated the testing of latent TB infection (LTBI) and recommended treatment from HCWs...
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Detection of Rifampicin Resistance in Mycobacterium tuberculosis by Using Middlebrook 7H9 Broth Medium with 2,3-Diphenyl-5-Thienyl-(2)-Tetrazolium Chloride

Lee SM, Kim KJ, Chang CL

BACKGROUND: A simple and cost-effective method is needed for the detection of rifampicin resistance in Mycobacterium tuberculosis in resource-limited settings. We suggest a broth medium-based method using 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride (STC)...
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Analysis of the Use of Medical Institutions and Prescription Drugs for Pulmonary Tuberculosis in Geriatric Patients

Moon SJ, Lee YS, Rhew K

BACKGROUND: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that can affect many organs of the body but usually affects the lungs. The prevalence of TB in Korea...
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Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea

Jo KW, Lee S, Kang MR, Sung H, Kim MN, Shim TS

BACKGROUND: A disputed rpoB mutation is a specific type of rpoB mutation that can cause low-level resistances to rifampin (RIF). Here, we aimed to assess the frequency and types of...
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Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes

Han KM, Ahn SY, Seo H, Yun J, Cha HJ, Shin JS, Kim YH, Kim H, Park HK, Lee YM

The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and...
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A prospective cohort study of latent tuberculosis in adult close contacts of active pulmonary tuberculosis patients in Korea

Park SH, Lee SJ, Cho YJ, Jeong YY, Kim HC, Lee JD, Kim HJ, Menzies D

BACKGROUND/AIMS: The objective of this prospective study was to evaluate the diagnosis and treatment of latent tuberculosis infection (LTBI) in adult close contacts of active pulmonary tuberculosis (TB) patients in...
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Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication

Lee YM, Huh KC, Yoon SM, Jang BI, Shin JE, Koo HS, Jung Y, Kim SH, Moon HS, Lee SW, Daejeon-Chungchung Intestinal Research Group

BACKGROUND/AIMS: To determine the incidence and clinical characteristics of tuberculosis (TB) medication-associated Clostridium difficile infection. METHODS: This multicenter study included patients from eight tertiary hospitals enrolled from 2008 to 2013. A...
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In vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi

Son D, Chung MH

BACKGROUND: To investigate whether chloroquine enhances the effect of antibiotics against Orientia tsutsugamushi, the causative organism of scrub typhus, we compared the effect of antibiotics in combination with chloroquine with...
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A Systematic Review on the Effectiveness of Detection of M. tuberculosis and Rifampin Resistance Using Xpert MTB/RIF

Jeong JY, Lee SH, Jang S

BACKGROUND: The purpose of this study was to evaluate the effectiveness of Xpert MTB/RIF (Cepheid, USA) in the detection of Mycobacterium tuberculosis and to determine rifampin resistance. METHODS: The literature review...
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A Case of Serum Sickness-Like Reaction and Anaphylaxis - Induced Simultaneously by Rifampin

Kim DH, Choi YH, Kim HS, Yu JE, Koh YI

Rifampin is commonly used as a first-line anti-tuberculosis drug, but it can induce a serum sickness-like reaction or anaphylaxis. However, it is possible for 1 drug antigen to induce 2...
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In Vitro Bacteriostatic Effects of Rifampin on Orientia tsutsugamushi

Im JH, Baek JH, Lee JS, Chung MH, Lee SM, Kang JS

We performed an in vitro cell culture experiment to ascertain whether rifampin exhibits bactericidal effects against Orientia tsutsugamushi, the causative agent of scrub typhus. ECV304 cells were infected with the...
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Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Moon SM, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH

Recurrent tuberculosis can be caused by a relapse of the original infecting strain, a reinfection with a new strain of Mycobacterium tuberculosis or a paradoxical response associated with the anti-tuberculosis...
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Evaluation of the AdvanSure MDR-TB GenoBlot Assay for Detection of Rifampin and Isoniazid Resistant Mycobacterium tuberculosis Complex in Respiratory Specimens

Kim J, Park YJ, Lee NY, Chang CL, Lee M, Shin JH

BACKGROUND: We evaluated the performance of the AdvanSure MDR-TB GenoBlot Assay kit (AdvanSure MDR-TB, LG Life Science, Korea) to detect mutations related to rifampin (RFP)- and isoniazid (INH)-resistant Mycobacterium tuberculosis...
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Clinical Usefulness of rpoB Gene Sequence Analysis in Lymph Node Tuberculosis

Park JY, Kwon KT

BACKGROUND: Lymph node tuberculosis (LN-TB), the most common extra-pulmonary tuberculosis, frequently shows a paradoxical response (PR) during treatment. Differential diagnosis between PR and treatment failure in LN-TB is a challenging...
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Rapid Diagnosis of Tuberculosis and Multidrug Resistance Using a MGIT 960 System

Koh WJ, Ko Y, Kim CK, Park KS, Lee NY

BACKGROUND: The purpose of this study was to compare the turnaround time for liquid culturing and primary anti-tuberculous drug susceptibility testing (DST) performed using the mycobacteria growth indicator tube (MGIT)...
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Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Induced by Ethambutol and Rifampin

Jung ES, Choi B, Choi HS, Kim BH, Ha M, Shin D, Park JS, Lee JR, Seo YH, Park YS

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a disorder which can be caused by treatment with a diverse collection of drugs, and it is characterized by fever,...
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A Case of Rifampin-Induced Recurrent Adrenal Insufficiency During the Treatment of Pulmonary Tuberculosis in a Patient with Addison's Disease

Kang JS, Ko GB, Lee JJ, Kim M, Jeon SJ, Choi GH, Kim SM, Lee WJ

Adrenal insufficiency during the treatment of pulmonary tuberculosis is a troublesome condition and can at times be lifethreatening if untreated. Rifampin is one of the most widely prescribed anti-tuberculosis agents....
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A Case of Rifampin-Induced Crescentic Glomerulonephritis

Lee KN, Song SH, Rhee H, Seong EY, Kim IY, Lee SB, Kwak IS

  • KMID: 2263652
  • Korean J Med.
  • 2012 Feb;82(2):236-240.
A 56-year-old male with pulmonary tuberculosis was admitted to our hospital for evaluation of generalized edema. He began antituberculosis treatment with rifampin, isoniazid, ethambutol, and pyrazinamide. He experienced abnormal increments...
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Fatal Hypersensitivity Reactions Induced by Re-Administration of Rifampin in an Immunocompetent Patient with Tuberculous Lymphadenopathy

Kim Y, Yim SY, Bae SI, Ahn JH, Chang WG, Sohn JW, Kim MJ

  • KMID: 2264209
  • Korean J Med.
  • 2012 Jan;82(1):115-118.
A 44-year-old patient who had been diagnosed with tuberculous lymphadenopathy came to our hospital with a rash. He began to take antituberculous medications, but the next day, a rash appeared...
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