Tissue Eng Regen Med.
2016 Feb;13(1):91-99. 10.1007/s13770-016-9086-0.
STX0119 Ameliorates Arthritis in SKG Mice via Inhibiting T Helper 17
- Affiliations
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- 1College of Pharmacy, Gachon University, Incheon, Korea. dyshin@gachon.ac.kr
- 2The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Korea. iammila@catholic.ac.kr
- 3Department of Orthopedic Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 4Impact Biotech, Seoul, Korea.
- 5Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 6Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul, Korea.
- 7Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- KMID: 2360871
- DOI: http://doi.org/10.1007/s13770-016-9086-0
Abstract
- Rheumatoid arthritis (RA) is an autoimmune disease with chronic and excessive inflammation. Upregulation of interleukin (IL)-17 is involved in the pathogenesis of RA. STX0119 is a specific inhibitor of signal transducer and activator of transcription 3 (STAT3) as a potential target for the treatment of RA. STAT3 is a member of DNA-binding molecules that regulates the expression of proinflammatory cytokines involved in the pathogenesis of RA. The objective of this study was to determine whether STX0119 could inhibit STAT3 and IL-17. We demonstrated that STX0119 decreased T helper (Th) 17 differentiation and IL-17 expression in vitro. STX0119 also improved the severity of zymosan induced arthritis and reduced joint inflammation. STX0119 reduced the proliferation of Th17 and phosphorylated STAT3 expression while increasing Treg differentiation and phosphorylated STAT5 expression. Moreover, STX0119 decreased the expression of IL-6 and -17 but not IL-10. These findings suggest that STX0119 can be used to treat autoimmune RA through inhibiting the activation of STAT3.
Keyword
MeSH Terms
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Animals
Arthritis*
Arthritis, Rheumatoid
Autoimmune Diseases
Cytokines
In Vitro Techniques
Inflammation
Interleukin-10
Interleukin-17
Interleukin-6
Interleukins
Joints
Mice*
STAT3 Transcription Factor
Up-Regulation
Zymosan
Cytokines
Interleukin-10
Interleukin-17
Interleukin-6
Interleukins
STAT3 Transcription Factor
Zymosan
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