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Pain modality and spinal glia expression by streptozotocin induced diabetic peripheral neuropathy in rats

Kim SH, Kwon JK, Kwon YB

Pain symptoms are a common complication of diabetic peripheral neuropathy or an inflammatory condition. In the most experiments, only one or two evident pain modalities are observed at diabetic peripheral...
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The Effect of Growth Hormone on TNF-alpha Level in Zymosan: A Induced Multiorgan Failure

Kim JT, Rhee JE, Jung SE, Youn YK, Oh SK

  • KMID: 2095245
  • J Korean Surg Soc.
  • 1997 Oct;53(4):461-469.
The pathogenesis of sepsis is not clearly understood. In animal models, the association of a high plasma TNF-alpha level with the frequent development of adult respiratory distress syndrome in septic...
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Korean Mistletoe (Viscum album Coloratum) Extract Induces Eel (Anguilla japonica) Non-specific Immunity

Yoon TJ, Park KH, Choi SH

BACKGROUND: The immunomodulatory effects of Korean mistletoe (Viscum album Coloratum) on the innate immune responses of eel (Anguilla japonica) were studied. METHODS: Mistletoe, Freund's complete adjuvant (FCA), or phosphate-buffered saline (PBS)...
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The Expression Pattern of Toll-like Receptor (TLR) and Cytokine Production to TLR Agonists in Human Retinal Pigment Epithelial Cells

Choi SJ, Lee KH, Park SJ, Park HS, Kim J, Kim SK, Park JY

Retinal pigment epithelium (RPE) constituting the outer blood-retina barrier plays an important role in ocular defense mechanism. Many studies reported that RPE participates in ongoing immune responses in the retina....
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Superoxide Anion Generation of Neutrophils in Patients with Atopic Dermatitis

Yeo UC, Kim SH

  • KMID: 1920688
  • Korean J Dermatol.
  • 1990 Dec;28(6):669-676.
Atopic dermatitis is characterized by many signs of immunodeficiency. We have performed this experiment to know whether there are reduced respiratoty burst of neutrophils in patients with atopic dermatitis in...
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Modulation of Antimicrobial Peptide Human beta-defensin-3 by Toll-like Receptor Ligands in Vaginal Epithelial Cells

Lee SY, Kim HJ, Chang IH, Han JH, Kim KD, Moon YT, Myung SC

PURPOSE: Vaginal epithelial cells have always been exposed to various pathogens. However, this has not always caused clinical infection. In addition to a previously reported protection effect of the vagina,...
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Dectin-1 Stimulation Selectively Reinforces LPS-driven IgG1 Production by Mouse B Cells

Seo BS, Lee SH, Lee JE, Yoo YC, Lee J, Park SR

Dectin-1, which specifically recognizes beta-glucan of fungal cell walls, is a non-Toll-like receptor (TLR) pattern recognition receptor and a representative of C-type lectin receptors (CLRs). The importance of Dectin-1 in...
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Effect of C . albicans on IL - 6 Gene Expression of Human Peripheral Blood Lymphocytes

Kim HS, Lee YS, Kim SK, Cha HS

  • KMID: 1548226
  • Korean J Immunol.
  • 1997 Jun;19(2):263-276.
The gene expressions of Interleukin-6 (IL-6) from human peripheral blood lymphocytes (HPBL) stimulated by C. albicans were investigated by using ELISA (Enzyme linked immunosorbent assay), reverse transcription polymerase chain reaction...
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Dose-Related Effects of Steroid on the Experimental Arthritis in Rabbits

Bak JY, Kim JS, Kim BH, Lee JH, Ahn KH

  • KMID: 2136708
  • J Korean Acad Rehabil Med.
  • 2001 Apr;25(2):284-289.
OBJECTIVE: To investigate dose-related effects of repeated intraarticular steroid injection on the experimental arthritis. METHOD: Twenty-four adult male rabbits received Zymosan A into their right knee joint for experimental arthritis. After...
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Adenosine Receptor Agonists Modulate Visceral Hyperalgesia in the Rat

Sohn CI, Park HJ, Gebhart GF

  • KMID: 2009155
  • Gut Liver.
  • 2008 Jun;2(1):39-46.
BACKGROUND/AIMS: Adenosine is an endogenous modulator of nociception. Its role in visceral nociception, particularly in visceral hyperalgesia, has not been studied. The aim of this study was to determine the...
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Xylitol Mitigate Neutrophil Inflammatory Response Against Porphyromonas gingivalis Infection

Na HS, Song Y, Choi YH, Chung J

Periodontitis is generally a chronic disorder characterized by breakdown of tooth-supporting tissues, producing dentition loss. Porphyromonas gingivalis (P. gingivalis), a Gram-negative anaerobic rod, is one of the major pathogens associated...
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STX0119 Ameliorates Arthritis in SKG Mice via Inhibiting T Helper 17

Hayat F, Lee SH, Lee EJ, Kim SJ, Jung K, Lee SK, Youn J, Min JK, Cho ML, Shin DY

Rheumatoid arthritis (RA) is an autoimmune disease with chronic and excessive inflammation. Upregulation of interleukin (IL)-17 is involved in the pathogenesis of RA. STX0119 is a specific inhibitor of signal...
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Phagocytosis of serum-and IgG-opsonized zymos an particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1

Kim JS, Kwon HY, Choi WH, Jeon CY, Kim JI, Kim J, Lee JY, Kim YS, Park JB

  • KMID: 1094703
  • Exp Mol Med.
  • 2003 Jun;35(3):211-221.
Phagocytosis of serum- and IgG-opsonized zymosan (SOZ and IOZ, respectively) particles into J774A.1 macrophages induced apoptosis of the cells, accompanied by the expression of p21(WAF1), one of cyclin-dependent protein kinase...
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An Appreciation of Functional Role of Macrophage in the Acute Lung Injury in the Neutropenic Rat

Kim YH, Ki SY, Im KI, Moon SH, Cheong SW, Kim HT, Uh ST, Park CS, Jin BW

BACKGROUND: It has long been suggested that neutrophils and their products are implicated as the central mediators of the acute lung injuries. Contrary to the dominant role of neutrophils in...
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Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages

Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB

  • KMID: 1116203
  • Exp Mol Med.
  • 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis...
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