J Korean Geriatr Psychiatry.  2016 Oct;20(2):75-79. 10.0000/jkgp.2016.20.2.75.

A Voxel Wise Analysis of Cerebral Beta Amyloid Retention in Healthy Controls and Subjects with Amnestic Mild Cognitive Impairment and Alzheimer's Disease

• Cho Y
• Um YH
• Kim TW
• Seo HJ
• Jeong JH
• Hong SC
• Han JH
• Baek IH
• Lim HK

• KMID: 2358085
• DOI: http://doi.org/10.0000/jkgp.2016.20.2.75

Abstract

OBJECTIVE
The purpose of the study was to compare cortical amyloid deposition using 18F-florbetaben and positron emission tomography (PET) in healthy controls and subjects with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD).
METHODS
We investigated 25 patients : 10 age-matched healthy controls, 10 patients with aMCI and 5 with AD. All participants underwent PET after intravenous injection of 300 MBq of 18F-florbetaben. The 90 min post-injection brain PET data were analysed using statistical parametric mapping.
RESULTS
When compared to healthy controls, amyloid deposition was significantly higher in frontal lobe medial frontal gyrus, limbic lobe posterior cingulate, parietal lobe precuneus, sub-loba insula, temporal lobe superior temporal gyrus, parietal lobe inferior parietal lobule, temporal lobe middle temporal gyrus, parietal lobe supramarginal gyrus, occipital lobe middle temporal gyrus of patient group (family wise error correction p<0.05).
CONCLUSION
These results indicate 18F-florbetaben to be an efficacious β-amyloid-targeted tracer. Subjects with aMCI, AD could be easily differentiated from healthy controls by assessment of the PET data.

Keyword

β-amyloid; Positron emission tomography; 18F-florbetaben; Alzheimer's disease

MeSH Terms

Alzheimer Disease*
Amyloid*
Brain
Frontal Lobe
Gyrus Cinguli
Humans
Injections, Intravenous
Limbic Lobe
Mild Cognitive Impairment*
Occipital Lobe
Parietal Lobe
Plaque, Amyloid
Positron-Emission Tomography
Prefrontal Cortex
Temporal Lobe
Amyloid