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Development of Efficient Brain Age Estimation Method Based on Regional Brain Volume From Structural Magnetic Resonance Imaging

Kim S, Wang SM, Kang DW, Um YH, Yang H, Lee H, Kim RE, Kim D, Lee CU, Lim HK

Objective We aimed to create an efficient and valid predicting model which can estimate individuals’ brain age by quantifying their regional brain volumes. Methods A total of 2,560 structural brain magnetic...
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Psychometric Properties of the Insomnia Severity Index and Its Comparison With the Shortened Versions Among the General Population

Chung S, Ahmed O, Cho E, Bang YR, Ahn J, Choi H, Um YH, Choi JW, Kim SJ, Jeon HJ

Objective The aim of this study was to explore the psychometric properties of the Insomnia Severity Index (ISI) based on modern test theory, such as item response theory (IRT) and...
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Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition

Choi IH, Wang SM, Um YH, Lim HK, Lee CU, Kang DW

Objective We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI)...
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Functional Connectivity Change Associated With Apolipoprotein E Allotypes Precedes Structural Connectivity and Neurodegeneration in Cognitive Normal Older Adults Without Cerebral Aβ Deposition

Wang SM, Kang DW, Um YH, Kim S, Lee CU, Lim HK

Objective Apolipoprotein E (APOE) gene is known to influence cerebral functional connectivity (FC) in Alzheimer’s disease continuum. We investigated association between APOE allotypes and FC, structural connectivity, and cortical thickness...
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Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition

Choi IH, Wang SM, Um YH, Lim HK, Lee CU, Kang DW

Objective: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI)...
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Mediation Effect of the Coping Strategies on the Relation Between Stress and Sleep Quality

Kim SM, Um YH, Kim TW, Seo HJ, Jeong JH, Hong SC

Objective Recently data has been accumulated regarding the role of coping strategies in the relationship between stress and sleep quality. Therefore, we set out to identify the mediating effects of...
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Melatonin and Alzheimer’s Disease: A Mini-Review

Um YH, Lim HK

Melatonin is a hormone with neuroregulatory, antioxidant and anti-inflammatory properties. Its benevolent effects on Alzheimer’s disease (AD) has been replicated in both animal models and clinical studies. Melatonin was effective...
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Suicide Risk in Patients With Diabetes Varies by the Duration of Diabetes: The Korea National Health and Nutrition Examination Survey (2019)

Kim YC, Um YH, Kim SM, Kim TW, Seo HJ, Hong SC, Jeong JH

Objective The objectives of this study were to investigate the suicide risk in diabetes patients and evaluate the variations in suicide risk by the duration of diabetes using a large...
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Association of Sub-Threshold Amyloid Retention With Neuropsychological Performance in Cognitively Normal Older Adults Without the APOE ε4 Allele

Choi JW, Wang SM, Um YH, Na HR, Kim NY, Lim HK, Lee CU, Kang DW

Objective: Recent evidence shows that the quantitative value of amyloid-beta (Aβ) deposition below the threshold of Aβ positivi-ty carries biological and clinical significance regarding future cognitive decline. We evaluated whether...
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Predictors of 1-Year Rehospitalization for Patients with Major Depressive Disorder: A Retrospective Study in a University Hospital

Yoo JM, Kim SM, Um YH, Kim TW, Seo HJ, Hong SC, Jeong JH

Background: This study aimed to assess the clinical characteristics of patients with major depressive disorder who were rehospitalized within 1 year and to determine whether the 1-year rehospitalization rate varied...
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Association between Dementia and Clinical Outcome after COVID-19: A Nationwide Cohort Study with Propensity Score Matched Control in South Korea

Wang SM, Park SH, Kim NY, Kang DW, Na HR, Um YH, Han S, Park SS, Lim HK

Objective Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses...
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Development of Random Forest Algorithm Based Prediction Model of Alzheimer’s Disease Using Neurodegeneration Pattern

Kim J, Lee M, Lee MK, Wang SM, Kim NY, Kang DW, Um YH, Na HR, Woo YS, Lee CU, Bahk WM, Kim D, Lim HK

Objective Alzheimer’s disease (AD) is the most common type of dementia and the prevalence rapidly increased as the elderly population increased worldwide. In the contemporary model of AD, it is...
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Korean Clinical Practice Guideline for the Diagnosis and Treatment of Insomnia in Adults

Choi H, Youn S, Um YH, Kim TW, Ju G, Lee HJ, Lee C, Lee SD, Bae K, Kim SJ, Lee JH, Kim T, Chung S

Objective We aim to present a clinical guideline for the diagnosis and treatment of insomnia in adults by reviewing and integrating existing clinical guidelines. The purpose of this guideline is...
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Correlation between Sleep and C-reactive Protein of Patients in Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia

Kim HY, Hong SC, Jeong JH, Seo HJ, Kim TW, Kim SM, Oh JH, Chung JS, Um YH

Objective: Sleep affects systemic inflammation and amyloid deposition, and sleep disturbance is known to be a risk factor for cognitive decline. To date, literatures on the relationship between peripheral inflammatory...
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Association of Alcohol Intake and Fracture Risk in Elderly Varied by Affected Bones: A Nationwide Longitudinal Study

Wang SM, Han KD, Kim NY, Um YH, Kang DW, Na HR, Lee CU, Lim HK

Objective Previous studies investigating association of alcohol intake and fracture risk in elderly yielded conflicting results. We first examined the association between alcohol intake and total fracture risk in elderly...
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Differential Impact of Cigarette Smoking on Fracture Risks in Subjective Cognitive Decline and Dementia: A Nationwide Longitudinal Study

Um YH, Wang SM, Han Kd, Kim NY, Kang DW, Na HR, Lee CU, Lim HK

Objective We aimed to explore the differential impact of cigarette smoking on fracture risks in SCD and dementia. Methods A nationwide population-based cohort study design was used. Out of all the...
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Orexin and Alzheimer’s Disease: A New Perspective

Um YH, Lim HK

Orexin’s role in human cognition has recently been emphasized and emerging evidences indicate its close relationship with Alzheimer’s disease (AD). This review aimed to demonstrate recent research on the relationship...
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Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Um YH, Wang SM, Kim NY, Kang DW, Na HR, Lee CU, Lim HK

Objective We aimed to explore the impact of moderate intensity exercise on the cortical thickness and subcortical volumes of preclinical Alzheimer’s disease (AD) patients. Methods Sixty-three preclinical AD patients with magnetic...
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Association between Glycemic Control in Patients with Diabetes and Mental Health Variables Including Depression

Lee H, Oh JH, Um YH, Kim SM, Kim TW, Seo HJ, Hong SC, Jeong JH

Background: The purpose of this study was to measure several mental health variables according to HbA1c level and examine their relationship among diabetic patients. Methods: Total 89 outpatients who attended diabetes...
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Anxiety and Depression of the Patients with Hematological Malignancies during Hospitalization for Hematopoietic Stem Cell Transplantation

Seo HJ, Baek YG, Cho BS, Kim TS, Um YH, Chae JH

OBJECTIVE: This study aimed to assess the anxiety and depression in patients undergoing hematopoietic stem cell transplantation (HSCT). METHODS: Eighty-seven adult patients with various hematologic diseases, who were scheduled to receive...
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