Clin Psychopharmacol Neurosci.  2018 Feb;16(1):109-113. 10.9758/cpn.2018.16.1.109.

Limbic Encephalitis Manifesting as Selective Amnesia and Seizure-like Activity: A Case Report

• Kim SY
• Um YH
• Lim SC
• Jeong JH

• KMID: 2405240
• DOI: http://doi.org/10.9758/cpn.2018.16.1.109

Abstract

Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histopathological evidence of medial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI-1) is an auto-antigen associated with LE. We report a 37-year-old male patient with LGI-1-related LE who presented with recurrent episodes of selective amnesia, seizure-like activity, confusion, and personality change. His symptoms were significantly improved with steroid therapy. Thorough differential diagnosis with consideration for autoimmune encephalitis should be in patients with presentation of symptoms, such as memory impairment, personality change and seizure-like activity, especially when other neurological diagnoses are excluded.

Keyword

Anti-LGI-1 antibody encephalitis; Neuropsychiatric symptoms; Steroid therapy

MeSH Terms

Adult
Amnesia*
Diagnosis
Diagnosis, Differential
Dihydroergotamine
Encephalitis
Glioma
Humans
Inflammation
Limbic Encephalitis*
Male
Memory
Memory, Short-Term
Seizures
Temporal Lobe
Dihydroergotamine