J Korean Epilepsy Soc.  2012 Dec;16(2):56-58.

A Case of Limbic Encephalitis Associated with Bilateral Ovarian Teratoma

• Park SG
• Shin DJ

Abstract

A specific type of paraneoplastic limbic encephalitis (PLE) has been associated with ovarian teratomas. Twenty-year-old female patient visited our clinic presenting with acute delirium and intermittent generalized tonic-clonic seizure for 1 day. The initial brain MRI showed the leptomeningeal enhancement without abnormality of brain parenchyme. CFS studies revealed pleocytosis (WBC: 18/mm2) while level of glucose and protein (82 mg/dL, 33.3 mg/dL, respectively) were within normal range. With the consideration of viral encephalitis, antiviral and anti-epileptic agent started to infuse intravenously. However, refractory seizure and confused mentality did not improve. On the further work-up, bilateral mature teratoma was found out at abdominal CT. After ovarian cystectomy, mental status recovered to alert and neurological symptoms such as seizure were improved. We reported with an young age patient of PLE with ovarian teratoma, which has been rarely reported.

Keyword

Paraneoplastic syndrome; Teratoma; Limbic encephalitis

MeSH Terms

Brain
Cystectomy
Delirium
Encephalitis, Viral
Female
Glucose
Humans
Leukocytosis
Limbic Encephalitis
Paraneoplastic Syndromes
Reference Values
Seizures
Teratoma
Glucose