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Promising Neuroimaging Biomarkers in Depression

Lai CH

The neuroimaging has been applied in the study of pathophysiology in major depressive disorder (MDD). In this review article, several kinds of methodologies of neuroimaging would be discussed to summarize...
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Distinct Topographical Patterns of Spike-Wave Discharge in Transgenic and Pharmacologically Induced Absence Seizure Models

Lee S, Hwang E, Lee M, Choi JH

Absence seizures (AS) are generalized non-convulsive seizures characterized by a brief loss of consciousness and spike-and-wave discharges (SWD) in an electroencephalogram (EEG). A number of animal models have been developed...
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Neuroanatomical Predictors of Dysphagia after Stroke: Voxel-Based Lesion Symptom Mapping Study

Pyun SB, Yoo HJ, Jung Y, Tae WS

OBJECTIVE: Dysphagia is a common consequence of stroke with a negative effect on the clinical outcome. Given these potential outcomes, it is important to identify the precursors to dysphagia after...
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Comparison of the Surgical Approaches for Frontal Traumatic Intracerebral Hemorrhage

Park ES, Moon SK, Eom KS

PURPOSE: Recent developments in minimally invasive techniques have the potential to reduce surgical morbidity, promote patient recovery, accelerate surgical procedures, and thus improve cost-effectiveness in case management. In this study,...
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Mechanism of Mindfulness-Based Intervention and Neurobiological Basis

Kim HG

Mindfulness is a process in which all thoughts, feelings, sensations, and all phenomena that happen to me are uncritically recognized as they are, so that they are eventually accepted and...
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Pilot Study: An Ocular Biomarker for Diagnosis of Attention Deficit Hyperactivity Disorder

Bae S, Kim JT, Han JM, Han DH

OBJECTIVE: Biomarkers of attention deficit hyperactivity disorder (ADHD) are crucial for early diagnosis and intervention, in which the identification of biomarkers in other areas of the body that represent the...
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The Correlation between Cognition Screening Scores and Gait Status from Three-Dimensional Gait Analysis

Choi J, Park J, Lee BI, Shin KJ, Yoo S, Kim H, Jang W, Kim JS, Youn J, Oh E

BACKGROUND AND PURPOSE: Gait impairment in patients with cognitive decline has received considerable attention over the past several decades. However, gait disturbance in dementia is often underdiagnosed. The Mini Mental...
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A Case of Recurrent Supratentorial Extraventricular Anaplastic Ependymoma in Adult

Seo SW, Kang HJ, Lee MS, Suh SJ, Lee YS, Lee JH, Kang DG

Supratentorial extraventricular anaplastic ependymoma (SEAE) in adults is a relatively rare intracranial tumor. Because of the very low prevalence, only a few cases have been reported. According to a recent...
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Effects of Amisulpride Adjunctive Therapy on Working Memory and Brain Metabolism in the Frontal Cortex of Patients with Schizophrenia: A Preliminary Positron Emission Tomography/Computerized Tomography Investigation

Park JH, Hong JS, Kim SM, Min KJ, Chung US, Han DH

OBJECTIVE: Dopamine plays a significant role in working memory by acting as a key neuromodulator between brain networks. Additionally, treatment of patients with schizophrenia using amisulpride, a pure dopamine class...
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Evaluation of Tumor Blood Flow Using Alternate Ascending/Descending Directional Navigation in Primary Brain Tumors: A Comparison Study with Dynamic Susceptibility Contrast Magnetic Resonance Imaging

Park H, Lee J, Park SH, Choi SH

OBJECTIVE: Alternate ascending/descending directional navigation (ALADDIN) is a novel arterial spin labeling technique that does not require a separate spin preparation pulse. We sought to compare the normalized cerebral blood...
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Neural Mechanism of Second Language Processing in Korean-English Bilingual Children

Lee YY, Baek BH, Kim SK, Park IW, Jeong GW, Baek S, Yoon W

PURPOSE: To evaluate the neural mechanism of second language processing in Korean-English bilingual children using functional MRI (fMRI). MATERIALS AND METHODS: The study was conducted on 20 Korean elementary school children...
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Utility of white matter to gray matter signal intensity ratio in comatose patients treated by targeted temperature management after cardiac arrest: a preliminary study

Keum KT, Kim YH, Hwang SY, Lee JH, Lee DW, Song YG, Lee JH, Lee KY

OBJECTIVE: This study examined the efficacy of the white matter (WM) to gray matter (GM) signal intensity ratio (SIR) in predicting the clinical prognosis of cardiac arrest patients. METHODS: Thirty-one patients...
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Brain Activation Related to Perspective-Taking in Adolescents: Differences from Adults

Park SK, Son JW, Lee S, Ghim HR, Lee SI, Shin CJ, Kim S, Ju G

OBJECTIVES: The purpose of this study was to investigate the differences between adolescents and adults, in the perspective-taking ability, as well as the brain activation patterns during the perspective-taking situation. METHODS:...
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Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET

Jeong J, Jeong YJ, Park KW, Kang DY

PURPOSE: To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB). METHODS: We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively...
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A Case of Primary Central Nervous System Vasculitis That Worsened Despite Early Corticosteroid Therapy

Yoon SY, Park KS, Park SH, Park JY

Primary central nervous system vasculitis (PCNSV) is rare, and the diagnosis is difficult to make because of its variable radiologic expressions. Early corticosteroid therapy often is effective. Herein we report...
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Diffusion Tensor Imaging and Quantitative Magnetic Resonance Volumetric Assessment in the Diagnosis of Hemimegalencephaly: A Case Report

Yoo SJ, Lee JY, Lee YJ, Park DW, Kim TY, Kim HJ

A 27-year-old female presented with repeated seizures. As the left frontal lobe volume was enlarged in comparison with the right frontal lobe, hemimegalencephaly was suggested. Abnormal white matter fiber tracts...
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fNIRS Assessment during an Emotional Stroop Task among Patients with Depression: Replication and Extension

Nishizawa , Kanazawa T, Kawabata Y, Matsubara , Maruyama S, Kawano M, Kinoshita , Koh J, Matsuo K, Yoneda H

OBJECTIVE: Accumulated evidence collected via functional near-infrared spectroscopy (fNIRS) has been reported with regard to mental disorders. A previous finding revealed that emotional words evoke left frontal cortex activity in...
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Fear Network Model in Panic Disorder: The Past and the Future

Lai CH

The core concept for pathophysiology in panic disorder (PD) is the fear network model (FNM). The alterations in FNM might be linked with disturbances in the autonomic nervous system (ANS),...
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Multiple brain abscesses treated by extraction of the maxillary molars with chronic apical lesion to remove the source of infection

Jung KH, Ro SS, Lee SW, Jeon JY, Park CJ, Hwang KG

BACKGROUND: Brain abscess is a life-threatening condition that occurs due to complications during a neurosurgical procedure, direct cranial trauma, or the presence of local or distal infection. Infection in the...
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¹⁸F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia

Yoon CW, Jeong HJ, Seo S, Lee SY, Suh MK, Heo JH, Lee YB, Park KH, Okamura N, Lee KM, Noh Y

BACKGROUND AND PURPOSE: To analyze 18F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA). METHODS: Thirty-one participants, including those with Alzheimer's disease (AD,...
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