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Distinct Neural Correlates of Executive Function by Amyloid Positivity and Associations with Clinical Progression in Mild Cognitive Impairment

Yoon HJ, Kim SG, Kim SH, Choo IH, Park SH, Seo EH, For the Alzheimer's Disease Neuroimaging Initiative

PURPOSE: This study aimed to identify the neural basis of executive function (EF) in amnestic mild cognitive impairment (aMCI) according to beta-amyloid (Aβ) positivity. Furthermore, we explored if the identified...
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Data-Driven Machine-Learning Quantifies Differences in the Voiding Initiation Network in Neurogenic Voiding Dysfunction in Women With Multiple Sclerosis

Karmonik C, Boone T, Khavari R

PURPOSE: To quantify the relative importance of brain regions responsible for reduced functional connectivity (FC) in their Voiding Initiation Network in female multiple sclerosis (MS) patients with neurogenic lower urinary...
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Promising Neuroimaging Biomarkers in Depression

Lai CH

The neuroimaging has been applied in the study of pathophysiology in major depressive disorder (MDD). In this review article, several kinds of methodologies of neuroimaging would be discussed to summarize...
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Clinical and neuroimaging determinants of minimally conscious and persistent vegetative states after acute stroke

Kumral E, Bayam FE, Köken B, Erdoğan C

BACKGROUND: Patients with persistent vegetative state (PVS) show no evidence of awareness of self or their environment, and those with minimally conscious state (MCS) have severely impaired consciousness with minimal...
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Spatiotemporal Analysis of Event-related Current Density Reveals Dissociable Effects of Arousal and Valence on Emotional Picture Processing

Yeo D, Kim H, Her S, Choi JW, Cha KS, Kim KH

BACKGROUND: The processing of emotional visual stimulation involves the processing of emotional and visuoperceptual information. It is not completely revealed how the valence and arousal affect these two aspects. The...
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Association Between Duration of Dysphagia Recovery and Lesion Location on Magnetic Resonance Imaging in Patients With Middle Cerebral Artery Infarction

Kim JH, Oh SH, Jeong HJ, Sim YJ, Kim DG, Kim GC

OBJECTIVE: To investigate association between lesion location on magnetic resonance imaging (MRI) performed after an infarction and the duration of dysphagia in middle cerebral artery (MCA) infarction. METHODS: A videofluoroscopic swallowing...
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Gray Matter Microstructural Abnormalities and Working Memory Deficits in Individuals with Schizophrenia

Kim H, Shon SH, Joo SW, Yoon W, Lee JH, Hur JW, Lee J

OBJECTIVE: Working memory impairments serve as prognostic factors for patients with schizophrenia. Working memory deficits are mainly associated with gray matter (GM) thickness and volume. We investigated the association between...
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The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials

De Cagna F, Fusar-Poli L, Damiani S, Rocchetti , Giovanna G, Mori A, Politi P, Brondino N

Several studies have demonstrated the neuromodulating function of oxytocin (OT) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression. Consequently, intranasal OT (IN-OT)...
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¹⁸F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia

Nam G, Jeong HJ, Kang JM, Lee SY, Seo S, Seo HE, Park KH, Yeon BK, Ido T, Shin DJ, Noh Y

BACKGROUND AND PURPOSE: Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and...
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Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts

Lee SM, Lee S, Kang WS, Jahng GH, Park HJ, Kim SK, Park JK

OBJECTIVE: Structural changes of brain areas have been reported in depressive disorder and suicidal behavior (SB), in which TPH1 also has been known as a promising candidate gene. We investigated...
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Dysfunctional Social Reinforcement Processing in Disruptive Behavior Disorders: An Functional Magnetic Resonance Imaging Study

Hwang S, Meffert H, VanTieghem MR, Sinclair S, Bookheimer SY, Vaughan B, Blair RJ

OBJECTIVE: Prior functional magnetic resonance imaging (fMRI) work has revealed that children/adolescents with disruptive behavior disorders (DBDs) show dysfunctional reward/non-reward processing of non-social reinforcements in the context of instrumental learning...
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Relationship between Autistic Spectrum Trait and Regional Cerebral Blood Flow in Healthy Male Subjects

Ota M, Matsuo J, Sato N, Teraishi T, Hori H, Hattori K, Kamio Y, Maikusa N, Matsuda H, Kunugi H

OBJECTIVE: Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate...
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Multimodal Assessment of Neural Substrates in Computerized Cognitive Training: A Preliminary Study

Na HR, Lim JS, Kim WJ, Jang JW, Baek MJ, Kim J, Park YH, Park SY, Kim S

BACKGROUND AND PURPOSE: Several studies have validated the clinical efficacy of computerized cognitive training applications. However, few studies have investigated the neural substrates of these training applications using simultaneous multimodal...
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Brain Functional Magnetic Resonance Imaging Cue-reactivity Can Predict Baclofen Response in Alcohol Use Disorders

Holla B, Karthik S, Biswal J, Viswanath , Jayarajan , Bharath RD, Venkatasubramanian G, Benegal V

OBJECTIVE: Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment...
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Effects of Uric Acid on the Alterations of White Matter Connectivity in Patients with Major Depression

Sohn H, Kwon MS, Lee SW, Oh J, Kim MK, Lee SH, Lee KS, Kim B

OBJECTIVE: Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of...
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Hydrocephalus in a Patient with Alzheimer's Disease

Kang MJ, Park YH, Kim S, Yi S

BACKGROUND: Normal pressure hydrocephalus (NPH) is an etiology of dementia that is reversible following cerebrospinal fluid shunt placement, however, surgical intervention not always clinically effective and the respons to shunt...
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Central Regulation of Micturition and Its Association With Epilepsy

Jang HJ, Kwon MJ, Cho KO

Micturition is a complex process involving the bladder, spinal cord, and the brain. Highly sophisticated central neural program controls bladder function by utilizing multiple brain regions, including pons and suprapontine...
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Obesity and Brain Positron Emission Tomography

Pak K, Kim SJ, Kim IJ

Obesity, an increasingly common problem in modern societies, results from energy intake chronically exceeding energy expenditure. This imbalance of energy can be triggered by the internal state of the caloric...
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Decreased White Matter Structural Connectivity in Psychotropic Drug-Naïve Adolescent Patients with First Onset Major Depressive Disorder

Suh E, Kim J, Suh S, Park S, Lee J, Lee J, Kim IS, Lee MS

OBJECTIVES: Recent neuroimaging studies focus on dysfunctions in connectivity between cognitive circuits and emotional circuits: anterior cingulate cortex that connects dorsolateral orbitofrontal cortex and prefrontal cortex to limbic system. Previous...
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Brain Hypometabolism in Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome

Jeong BM, Shin BS, Seo MW, Park JY, Jeong HJ, Oh SY

Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is a slowing progressive ataxic disorder characterized by bilateral vestibulopathy, cerebellar ataxia and somatosensory impairment. Autonomic dysfunction is recently considered as...
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