Biomol Ther.
2016 Jul;24(4):426-432. 10.4062/biomolther.2015.169.
Cytoprotective Mechanism of Cyanidin and Delphinidin against Oxidative Stress-Induced Tenofibroblast Death
- Affiliations
-
- 1Department of Orthopaedic Surgery, School of Medicine and Hospital, Gyeongsang National University, Jinju 52727, Republic of Korea.
- 2Biomedical Research Institute, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea.
- 3Department of Environmental Material Science, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
- 4Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
- 5School of Medicine, Gyeongsang National University, Jinju 52727, Republic of Korea. hbinpark@gnu.ac.kr
- KMID: 2351692
- DOI: http://doi.org/10.4062/biomolther.2015.169
Abstract
- Age-related rotator cuff tendon degeneration is related to tenofibroblast apoptosis. Anthocyanins reduce oxidative stress-induced apoptotic cell death in tenofibroblasts. The current study investigated the presence of cell protective effects in cyanidin and delphinidin, the most common aglycon forms of anthocyanins. We determined whether these anthocyanidins have antiapoptotic and antinecrotic effects in tenofibroblasts exposed to H₂O₂, and evaluated their biomolecular mechanisms. Both cyanidin and delphinidin inhibited H₂O₂-induced apoptosis in a dose-dependent manner. However, at concentrations of 100 μg/ml or greater, delphinidin showed cytotoxicity against tenofibroblasts and a decreased antinecrotic effect. Cyanidin and delphinidin both showed inhibitory effects on the H₂O₂-induced increase in intracellular ROS formation and the activation of ERK1/2 and JNK. In conclusion, both cyanidin and delphinidin have cytoprotective effects on cultured tenofibroblasts exposed to H₂O₂. These results suggest that cyanidin and delphinidin are both beneficial for the treatment of oxidative stress-mediated tenofibroblast cell death, but their working concentrations are different.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Epilepsy and Oxidative Stress
- Cyanidin-3-glucoside inhibits amyloid β₂₅₋₃₅-induced neuronal cell death in cultured rat hippocampal neurons
- Black rice extract protected HepG2 cells from oxidative stress-induced cell death via ERK1/2 and Akt activation
- 6'-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage
- Delphinidin enhances radio-therapeutic effects via autophagyinduction and JNK/MAPK pathway activation in non-small celllung cancer
