J Korean Soc Endocrinol.  1997 Jun;12(2):308-314.

A Case of Partial Hypopituitarism and Central Diabetes Insipidus Developed after Tuberculous Meningitis

• Yoo SJ
• Yoon KH
• Kang MI
• Cha BY
• Lee KW
• Son HY
• Kang SK
• Chung MH
• Shin Y
• Kwon HS
• Jin SW

Abstract

Complications related to tuberculous menngitis (TBM) is frequently encountered in medical field during, just after treatment and long time later. Hypothalamo-pituitary dysfunctions such as diabetes incipidus, dwarfism, hypogonadism, growth failure, and hypopituitarism are one of rare complication secondary to TBM and of which obesity with hypogonadism is most commonly documented. Several pathologic mechanics like a granuloma in hypothalamus, or pituitary stalk, organization and progressive scarring of the purulent exudate in the basal cistern or progressive obliterative endarteritis that supplying the hypothalamo-hypophyseal system is well-defined in hypothalamopituitary dysfunction in neurotuberculosis. We recently experienced a diabetic patient with short stature and sexual infantilism who shows polyuria and polydipsia. Detailed endocrinological evaluation showed partial hypopituitarism and central diabetes incipidus secondary to tuberculous meningitis. Polyuria and polydipsia was improved with dDAVP and height increased 5 cm for 11 month with HGH, libido increased with oxadrolone but his extemal sexual characteristics was not changed until now. We present this case with a review of literature.

MeSH Terms

Cicatrix
Deamino Arginine Vasopressin
Diabetes Insipidus, Neurogenic*
Diabetes Mellitus
Dwarfism
Endarteritis
Exudates and Transudates
Granuloma
Humans
Hypogonadism
Hypopituitarism*
Hypothalamo-Hypophyseal System
Hypothalamus
Libido
Mechanics
Obesity
Pituitary Gland
Polydipsia
Polyuria
Sexual Infantilism
Tuberculosis, Meningeal*
Deamino Arginine Vasopressin