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Shinjulactone A Blocks Vascular Inflammation and the EndothelialMesenchymal Transition

Jang Ye, Immanuel J, Lee Jr, Jang Yj, Kwon YJ, Kwon HS, Shin JW, Yun S

Objective: The endothelial inflammatory response plays an important role in atherogenesis by inducing nuclear factor (NF)κB-dependent cell adhesion molecule expression and monocyte recruitment. Here, we screened for natural ligands and...
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Prenatal Diagnosis of Congenital Heart Diseases and Associations with Serum Biomarkers of Aneuploidy: A Multicenter Prospective Cohort Study

Wie JH, Han YJ, Kim SH, Kim MY, Cho HY, Lee MY, Chung JH, Lee SM, Oh Sy, Lee JH, Boo HY, Cho GJ, Kwon HS, Kim BJ, Park MH, Ryu HM, Ko HS

Purpose: We assessed prenatal detection rates of congenital heart disease (CHD) and associations between maternal serum biomarkers and non-chromosomal CHD in singleton pregnancies. Materials and Methods: This study was conducted as...
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Management of hereditary angioedema in pediatric, pregnant, and breast-feeding patients: An expert opinion

Yoon SY, Jung JW, Park SY, Kim GW, Son K, Kang SY, Park HJ, Kang MK, Kim JH, Park KH, Lee DH, Kim SH, Kwon HS, Kang HR, Suh DI

Hereditary angioedema (HAE) is a rare inherited condition marked by recurrent skin and submucosal edema. HAE is caused by a C1 inhibitor deficiency or decreased C1 inhibitor function. The initial...
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Prediction of the composition of urinary stones using deep learning

Kim US, Kwon HS, Yang W, Lee W, Choi C, Kim JK, Lee SH, Rim D, Han JH

Purpose: This study aimed to predict the composition of urolithiasis using deep learning from urinary stone images. Materials and Methods: We classified 1,332 stones into 31 classes according to the stone...
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Diagnosis and treatment of hereditary angioedema: An expert opinion

Jung JW, Park SY, Yoon SY, Kim GW, Sohn KH, Kang SY, Park HJ, Kang MK, Kim JH, Park KH, Suh DI, Lee DH, Kim SH, Kwon HS, Kang HR

Hereditary angioedema (HAE) is a rare disease, but it severely interrupts daily life activities and can sometimes be life-threatening. Therefore, early diagnosis and prompt treatment of HAE attacks are critical....
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Perinatal Outcomes According to Accessibility to Maternal-Fetal and Neonatal Intensive Care Units by Region in Korea

Lee JH, Kwon HS, Noh YM, Shin H, Kim T, Lee TH, Chang YS

Background: Herein, we aimed to evaluate the maternal mortality ratio and perinatal mortality rate for different perinatal medical care service areas (PMCSAs), which were established by considering their geographical accessibility...
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Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients

Lee JH, Lee CE, Yoo Y, Shin E, An J, Park SY, Song WJ, Kwon HS, Cho YS, Moon HB, Kim TB

Background: Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of...
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Validation of a Strict Obesity Definition Proposed for Asians to Predict Adverse Pregnancy Outcomes in Korean Pregnant Women

Kim SY, Oh Sy, Sung JH, Choi SJ, Roh CR, Lee SM, Jun JK, Lee MY, Lee J, Kim SH, Cha DH, Han YJ, Kim MH, Cho GJ, Kwon HS, Kim BJ, Park MH, Cho HY, Ko HS, Shim JY, Ryu HM

Background: People are generally considered overweight and obese if their body mass index (BMI) is above 25 kg/m 2 and 30.0 kg/m 2 , respectively. The World Health Organization proposed...
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Comparison of the Effects of Various Antidiabetic Medication on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus

Ha J, Lim Y, Kim MK, Kwon HS, Song KH, Ko SH, Kang MI, Moon SD, Baek KH

Background: Prospective comparative studies on the effects of various antidiabetic agents on bone metabolism are limited. This study aimed to assess changes in bone mass and biochemical bone markers in...
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Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study

Koh ES, Han KD, Kim MK, Kim ES, Lee MK, Nam GE, Kwon HS

Background/Aims: Because weight control is important in treatment of type 2 diabetes, it is essential to understand the associations between weight change and the risk of microvascular complications among patients...
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Long-Term Changes in Post-Stroke Depression, Emotional Incontinence, and Anger

Kwon B, Lee EJ, Park S, Lee JS, Lee MH, Jeong D, Lee D, Kwon HS, Chang DI, Park JH, Cha JK, Heo JH, Sohn SI, Kim DE, Choi-Kwon S, Kim JS

Background and Purpose Long-term changes in post-stroke depression (PSD), post-stroke emotional incontinence (PSEI), and post-stroke anger (PSA) have rarely been studied. Methods This is a sub-study of EMOTION, a randomized, placebo-controlled...
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Adverse Reactions of the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine in Healthcare Workers in Korea

Lee YW, Lim SY, Lee JH, Lim JS, Kim M, Kwon S, Joo J, Kwak SH, Kim EO, Jung J, Kwon HS, Kim TB, Kim SH, Bae S

We conducted a prospective, mobile-based survey on the self-reported adverse reactions in healthcare workers (HCWs) who received both doses of the BNT162b2 mRNA vaccine. Of the 342 HCWs who completed...
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Adverse Reactions Following the First Dose of ChAdOx1 nCoV-19 Vaccine and BNT162b2 Vaccine for Healthcare Workers in South Korea

Bae S, Lee YW, Lim SY, Lee JH, Lim JS, Lee S, Park S, Kim SK, Lim YJ, Kim EO, Jung J, Kwon HS, Kim TB, Kim SH

Background: We performed a prospective survey on the adverse reactions following the first dose of two types of vaccines against coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs) in South...
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Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study

Lee SH, Min KW, Lee BW, Jeong IK, Yoo SJ, Kwon HS, Choi YH, Yoon KH

Background Glycemic variability is associated with the development of diabetic complications and hypoglycemia. However, the effect of sodium-glucose transporter 2 (SGLT2) inhibitors on glycemic variability is controversial. We aimed to examine...
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Nitrogen Dioxide Exposure May Be Associated with Poststroke Emotional Symptoms

Kwon HS, Lee EJ, Lee D, Lee JS, Kim JS

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Causes, Risk Factors, and Clinical Outcomes of Stroke in Korean Young Adults: Systemic Lupus Erythematosus is Associated with Unfavorable Outcomes

Kwon HS, Kim YS, Lee JM, Koh SH, Kim HY, Kim C, Lee SH, Jung KH, Kim YD, Kwon HM, Kim BJ, Kim JM, Kim BJ, Heo SH, Chang DI, on Behalf of the SKY Investigators

Background and Purpose: The incidence of ischemic stroke (IS) in young adults is increasing, and the associated large socioeconomic impact makes understanding IS in young adults important. We investigated the...
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Management of isolated oligohydramnios in Korea: a questionnaire-based study of clinical practice patterns among the members of the Korean Society of Maternal Fetal Medicine

Yang SW, Jin Y, Jang Eb, Kim HS, Sohn IS, Kwon HS, Hwang HS

Objective The aim of this survey was to investigate the recommendations and clinical practice patterns of the Korean Society of Maternal and Fetal Medicine (KSMFM) members, regarding management of isolated oligohydramnios...
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The Effect of Cognitive Training in a Day Care Center in Patients with Early Alzheimer’s Disease Dementia: A Retrospective Study

Kwon HS, Yang Hr, Yun K, Baek JS, Kim YU, Park S, Choi H

Objective This study aimed to evaluate the effect of cognitive training programs on the progression of dementia in patients with early stage Alzheimer’s disease dementia (ADD) at the day care...
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γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial

Won JC, Kwon HS, Moon SS, Chun SW, Kim CH, Park IB, Kim IJ, Lee J, Cha BY, Park TS

BackgroundThis study was a multicenter, parallel-group, double-blind, double-dummy, randomized, noninferiority trial to evaluate the efficacy and safety of γ-linolenic acid (GLA) relative to α-lipoic acid (ALA) over a 12-week treatment period in...
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Erratum: Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Kim HJ, Lee J, Kim JH, Park SY, Kwon HS, Kim TB, Moon HB, Cho YS

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