- Severe Hyponatremia during Acyclovir Treatment in Shingles
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Shin J, Kim M, Yoo JR, Kang SY, Oh JH
- KMID: 2470478
- Korean J Neuromuscul Disord.
- 2019 Dec;11(2):55-58.
- doi: 10.0000/kjnd.2019.11.2.55
Acyclovir is effective in treating the herpes virus infection, especially chickenpox and shingles. Hyponatremia caused by acyclovir has been rarely reported. We present a shingles patient with symptomatic hyponatremia that... -
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- The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance
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Feng JH, Lee HJ, Suh HW
- KMID: 2468884
- Exp Neurobiol.
- 2019 Dec;28(6):670-678.
- doi: 10.5607/en.2019.28.6.670
In the present study, the productions of antinociception induced by acute and chronic immobilization stress were compared in several animal pain models. In the acute immobilization stress model (up to... -
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- Regulation of estrous cycle by Cynodon dactylon in letrozole induced polycystic ovarian syndrome in Wistars albino rats
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Nallathambi A, Bhargavan
- KMID: 2466705
- Anat Cell Biol.
- 2019 Dec;52(4):511-517.
- doi: 10.5115/acb.19.114
Menstrual cycle is controlled by luteinizing hormone (LH) and follicle-stimulating hormone of anterior pituitary and regulated by gonadotropin-releasing hormone of hypothalamus. Any disturbance to this regulatory mechanism alters the pulsatile... -
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- Mechanisms of action and clinical applications of anti-obesity drugs currently available in Korea
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Kim KK
- KMID: 2462242
- J Korean Med Assoc.
- 2019 Nov;62(11):588-597.
- doi: 10.5124/jkma.2019.62.11.588
Over the last 5 years, the Korean Ministry of Food and Drug Safety has approved four anti-obesity drugs for long-term weight management. In this review, the mechanisms of action and... -
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- Food Craving, Seeking, and Consumption Behaviors: Conceptual Phases and Assessment Methods Used in Animal and Human Studies
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Lee YH, Kim M, Lee M, Shin D, Ha DS, Park JS, Kim YB, Choi HJ
- KMID: 2459809
- J Obes Metab Syndr.
- 2019 Sep;28(3):148-157.
- doi: 10.7570/jomes.2019.28.3.148
What drives us to eat? It is one of the most fundamental questions in the obesity research field which have been investigated for centuries. Numerous novel in vivo technologies in... -
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- Central Sleep Apnea without Cheyne-Stokes Breathing Following an Acute Cerebral Infarction
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Oh HJ, Woo HG, Seok JM, Yang KI
- KMID: 2452870
- J Sleep Med.
- 2019 Jun;16(1):53-55.
- doi: 10.13078/jsm.19017
Central sleep apnea (CSA) is attributed to medical or neurological conditions including stroke. The association of lesion location and CSA in patients with ischemic stroke has not been well elucidated.... -
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- Evaluation of infertility efficacy of the E. coli expressed STF2-GnRH vaccine in male cats
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Lee YJ, Jo EJ, Lee HW, Hwang BR, Kim YH, Park BJ, Cho YJ, Lee YA, Choi IS, Han JS
- KMID: 2448714
- J Vet Sci.
- 2019 May;20(3):e30.
- doi: 10.4142/jvs.2019.20.e30
Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus and anti-GnRH antibodies are not formed under normal conditions. However, administration an excess of recombinant GnRH protein results in the formation of... -
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- Updates on structural neuroimaging of narcolepsy with cataplexy
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Joo EY
- KMID: 2469522
- Precis Future Med.
- 2019 Mar;3(1):1-9.
- doi: 10.23838/pfm.2018.00149
Narcolepsy is a chronic neurological disorder associated with abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and rapid eye movement (REM) sleep phenomena including... -
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- Duodenal-Jejunal Bypass Surgery Stimulates the Expressions of Hepatic Sirtuin1 and 3 and Hypothalamic Sirtuin1
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Ha E, Kang JY, Park KS, Seo YK, Ha TK
- KMID: 2436617
- J Obes Metab Syndr.
- 2018 Dec;27(4):248-253.
- doi: 10.7570/jomes.2018.27.4.248
BACKGROUND: Sirtuins mediate metabolic responses to nutrient availability and slow aging and accompanying decline in health. This study was designed to assess the expressions of sirtuin1 (SIRT1) and sirtuin3 (SIRT3)... -
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- Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions
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Park YM, Chun H, Shin JI, Lee CJ
- KMID: 2430108
- Exp Neurobiol.
- 2018 Dec;27(6):508-525.
- doi: 10.5607/en.2018.27.6.508
Astrocyte is the most abundant cell type in the central nervous system and its importance has been increasingly recognized in the brain pathophysiology. To study in vivo function of astrocyte,... -
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- Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats
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Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS
- KMID: 2426331
- Yonsei Med J.
- 2018 Dec;59(10):1174-1180.
- doi: 10.3349/ymj.2018.59.10.1174
PURPOSE: Growth hormone secretagogues (GHSs) possess the ability to release growth hormone (GH) in the body. This study aimed to investigate the effects of MK-677, an orally active GHS, on... -
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- From Gut to Brain: Alteration in Inflammation Markers in the Brain of Dextran Sodium Sulfate-induced Colitis Model Mice
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Do J, Woo J
- KMID: 2428972
- Clin Psychopharmacol Neurosci.
- 2018 Nov;16(4):422-433.
- doi: 10.9758/cpn.2018.16.4.422
OBJECTIVE: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain... -
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- Evodiamine Reduces Caffeine-Induced Sleep Disturbances and Excitation in Mice
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Ko YH, Shim KY, Lee SY, Jang CG
- KMID: 2421720
- Biomol Ther.
- 2018 Sep;26(5):432-438.
- doi: 10.4062/biomolther.2017.146
Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This... -
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- Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2
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Kim M, de la Peña JB, Cheong JH, Kim HJ
- KMID: 2420386
- Biomol Ther.
- 2018 Jul;26(4):358-367.
- doi: 10.4062/biomolther.2017.131
Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the... -
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- Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression
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Yayeh T, Leem YH, Kim KM, Jung JC, Schwarz J, Oh KW, Oh S
- KMID: 2421735
- Biomol Ther.
- 2018 May;26(3):268-273.
- doi: 10.4062/biomolther.2017.083
Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been... -
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- Hepatopulmonary syndrome caused by hypothalamic obesity and nonalcoholic fatty liver disease after surgery for craniopharyngioma: a case report
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Jung D, Seo GH, Kim YM, Choi JH, Yoo HW
- KMID: 2409791
- Ann Pediatr Endocrinol Metab.
- 2018 Mar;23(1):51-55.
- doi: 10.6065/apem.2018.23.1.51
Hypothalamic obesity is often complicated in patients with craniopharyngioma due to hypothalamic damage by the tumor itself, treatment modalities, and associated multiple pituitary hormone deficiency. Hypothalamic obesity causes secondary diseases... -
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- Korean red ginseng excitation of paraventricular nucleus neurons via non-N-methyl-D-aspartate glutamate receptor activation in mice
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Shen Y, Bhattarai , Park SJ, Lee GS, Ryu PD, Han SK
- KMID: 2407616
- J Vet Sci.
- 2018 Mar;19(2):172-178.
- doi: 10.4142/jvs.2018.19.2.172
It has been reported that Korean red ginseng (KRG), a valuable and important traditional medicine, has varied effects on the central nervous system, suggesting its activities are complicated. The paraventricular... -
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- 4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1
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Kinyua AW, Ko CM, Doan KV, Yang DJ, Huynh MK, Moh SH, Choi YH, Kim KW
- KMID: 2440019
- Exp Mol Med.
- 2018 Feb;50(2):e437.
- doi: 10.1038/emm.2017.253
4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have... -
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- Udenafil, a Phosphodiesterase 5 Inhibitor, Reduces Body Weight in High-Fat-Fed Mice
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Ryu SY, Choi YJ, Park SY, Kim JY, Kim YD, Kim YW
- KMID: 2399170
- World J Mens Health.
- 2018 Jan;36(1):41-49.
- doi: 10.5534/wjmh.17028
PURPOSE: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in... -
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- Differential Tissue-specific and Pathway-specific Anti-obesity Effects of Green Tea and Taeumjowitang, a Traditional Korean Medicine, in Mice
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Kim J, Park S, An H, Choi JY, Choi MS, Choi SW, Kim SJ
- KMID: 2396163
- J Cancer Prev.
- 2017 Sep;22(3):147-158.
- doi: 10.15430/JCP.2017.22.3.147
BACKGROUND: Traditional medicines have been leveraged for the treatment and prevention of obesity, one of the fastest growing diseases in the world. However, the exact mechanisms underlying the effects of... -
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