J Korean Neurol Assoc.  2002 Mar;20(2):191-194.

A Case of Multiple Sclerosis Involving Hypothalamus

Affiliations
  • 1Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Korea. kkkim@www.amc.seoul.kr

Abstract

Lesions of multiple sclerosis (MS) are rarely distributed in deep gray matter. We report a case of MS with hypothala-mic lesions. A 26-year-old woman with MS developed hyperphagia, hypersomnolence, and amenorrhea. Brain MRI revealed bilateral lesions in both hypothalamus and thalamus. Serum prolactin concentration was increased and thyroid stimulating hormone (TSH) level was decreased. Three months after steroid pulse therapy, her symptoms were com-pletely resolved and prolactin concentration became normal Follow-up brain MRI demonstrated complete disappear-ance of previous lesions.

Keyword

Multiple Sclerosis; Hypothalamus

MeSH Terms

Adult
Amenorrhea
Brain
Disorders of Excessive Somnolence
Female
Follow-Up Studies
Humans
Hyperphagia
Hypothalamus*
Magnetic Resonance Imaging
Multiple Sclerosis*
Prolactin
Thalamus
Thyrotropin
Prolactin
Thyrotropin
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