J Korean Neurol Assoc.
2002 Mar;20(2):191-194.
A Case of Multiple Sclerosis Involving Hypothalamus
- Affiliations
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- 1Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Korea. kkkim@www.amc.seoul.kr
Abstract
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Lesions of multiple sclerosis (MS) are rarely distributed in deep gray matter. We report a case of MS with hypothala-mic lesions. A 26-year-old woman with MS developed hyperphagia, hypersomnolence, and amenorrhea. Brain MRI revealed bilateral lesions in both hypothalamus and thalamus. Serum prolactin concentration was increased and thyroid stimulating hormone (TSH) level was decreased. Three months after steroid pulse therapy, her symptoms were com-pletely resolved and prolactin concentration became normal Follow-up brain MRI demonstrated complete disappear-ance of previous lesions.