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Appetite Control Mechanisms and Obesity

Roh E

Dysregulated energy homeostasis leads to obesity. The brain, particularly hypothalamus and brain stem, plays a key role in the control of food intake and homeostatic regulation of energy metabolism. Food...
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Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake

Ha GE, Cheong E

  • KMID: 2524035
  • Exp Neurobiol.
  • 2021 Dec;30(6):375-386.
  • doi: 10.5607/en21037
Stress activates the hypothalamic-pituitary-adrenal system, and induces the release of glucocorticoids, stress hormones, into circulation. Many studies have shown that stress affects feeding behavior, however, the underlying circuitry and molecular...
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Deep brain stimulation for obesity or binge-eating behavior: an overview

Roh H, Kim JH

Obesity is a global epidemic, leading to huge burdens on both individuals and society. Non-invasive approaches, such as lifestyle modification or medication, have been regarded as a first-line treatment. However,...
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Dopaminergic Control of the Feeding Circuit

Baik JH

There is increasing evidence demonstrating that reward-related motivational food intake is closely connected with the brain’s homeostatic system of energy balance and that this interaction might be important in the...
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Perioperative glucocorticoid management based on current evidence

Seo KH

Glucocorticoid preparations, adreno-cortical steroids, with strong anti-inflammatory and immunosuppressive effects, are widely used for treating various diseases. The number of patients exposed to steroid therapy prior to surgery is increasing....
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Mechanisms of action and clinical applications of anti-obesity drugs currently available in Korea

Kim KK

Over the last 5 years, the Korean Ministry of Food and Drug Safety has approved four anti-obesity drugs for long-term weight management. In this review, the mechanisms of action and...
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Food Craving, Seeking, and Consumption Behaviors: Conceptual Phases and Assessment Methods Used in Animal and Human Studies

Lee YH, Kim M, Lee M, Shin D, Ha DS, Park JS, Kim YB, Choi HJ

What drives us to eat? It is one of the most fundamental questions in the obesity research field which have been investigated for centuries. Numerous novel in vivo technologies in...
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Hepatopulmonary syndrome caused by hypothalamic obesity and nonalcoholic fatty liver disease after surgery for craniopharyngioma: a case report

Jung D, Seo GH, Kim YM, Choi JH, Yoo HW

Hypothalamic obesity is often complicated in patients with craniopharyngioma due to hypothalamic damage by the tumor itself, treatment modalities, and associated multiple pituitary hormone deficiency. Hypothalamic obesity causes secondary diseases...
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Udenafil, a Phosphodiesterase 5 Inhibitor, Reduces Body Weight in High-Fat-Fed Mice

Ryu SY, Choi YJ, Park SY, Kim JY, Kim YD, Kim YW

PURPOSE: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in...
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Nonalcoholic fatty liver disease in long-term survivors of childhood-onset craniopharyngioma

Jung SY, Lee YJ, Lee HJ, Lee YA, Moon JS, Ko JS, Yang SW, Shin CH

PURPOSE: Hypothalamic obesity in childhood-onset (CO-) craniopharyngioma patients may predispose to nonalcoholic fatty liver disease (NAFLD). This study reviewed the characteristics of NAFLD associated with CO-craniopharyngioma. METHODS: This study retrospectively reviewed...
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Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density?

Jang M, Park SY, Kim YW, Jung SP, Kim JY

BACKGROUND: The proportion of saturated fatty acids/unsaturated fatty acids in the diet seems to act as a physiological regulation on obesity, cardiovascular diseases, and diabetes. Differently composed fatty acid diets...
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Brain Regulation of Energy Metabolism

Roh E, Kim MS

In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of...
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Matrix-assisted laser desorption ionization-time of flight mass spectrometry based identification of Edwardsiella ictaluri isolated from Vietnamese striped catfish (Pangasius hypothalamus)

Nhu TQ, Park SB, Kim SW, Lee JS, Im SP, Lazarte JM, Seo JP, Lee WJ, Kim JS, Jung TS

Edwardsiella (E.) ictaluri is a major bacterial pathogen that affects commercially farmed striped catfish (Pangasius hypothalamus) in Vietnam. In a previous study, 19 strains of E. ictaluri collected from striped...
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Hypothalamic Extraventricular Neurocytoma (EVN) in a Pediatric Patient: A Case of EVN Treated with Subtotal Removal Followed by Adjuvant Radiotherapy

Cho M, Joo JD, Kim BH, Choe G, Kim CY

Extra ventricular neurocytoma (EVN) is a rare brain tumor with histologic features similar with a central neurocytoma, but located outside of the ventricular system. In this study, we present an...
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Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake

Yoon YR, Baik JH

BACKGROUND: The melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food...
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Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders

Clarke H, Dhillo WS, Jayasena C

Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone...
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How Leptin Controls the Drive to Eat

Patterson , Myers MG

  • KMID: 2271158
  • Korean J Obes.
  • 2015 Jun;24(2):69-77.
A complex set of brain based systems modulate feeding to maintain constant body weight. The adipose derived-hormone, leptin, plays a crucial role in this control by acting on diverse leptin...
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Electroacupuncture Analgesia Is Improved by Adenoviral Gene Transfer of Dopamine Beta-hydroxylase into the Hypothalamus of Rats

Kim SJ, Chung ES, Lee JH, Lee CH, Kim SK, Lee HJ, Bae H

Electroacupuncture (EA) is a modified form of acupuncture that utilizes electrical stimulation. We previously showed that EA stimulated rats were divided into responders that were sensitive to EA and non-responders...
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Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents

Kim JH, Choi JH

The hypothalamus plays a key role in the regulation of body weight by balancing the intake of food, energy expenditure, and body fat stores, as evidenced by the fact that...
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Effects of Chronic Restraint Stress on Body Weight, Food Intake, and Hypothalamic Gene Expressions in Mice

Jeong JY, Lee DH, Kang SS

BACKGROUND: Stress affects body weight and food intake, but the underlying mechanisms are not well understood. METHODS: We evaluated the changes in body weight and food intake of ICR male mice...
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