Neonatal Med.  2016 Nov;23(4):228-232. 10.5385/nm.2016.23.4.228.

Neonatal Group B Streptococcal Meningitis Complicated with Secondary Hypopituitarism: A Case Report

• Lee H
• Lee SW
• Shim SY
• Park EA
• Cho SJ

• KMID: 2360463
• DOI: http://doi.org/10.5385/nm.2016.23.4.228

Abstract

Group B Streptococcus (GBS) commonly causes neonatal meningitis and sepsis. In infants with late-onset meningitis, fever, irritability or lethargy or both, poor feeding, and tachypnea are common initial signs. Major neurologic sequelae are observed in 29% of children, the most serious including global or profound mental retardation, spastic quadriplegia, cortical blindness, deafness, uncontrolled seizures, hydrocephalus, and hypothalamic dysfunction. We report a 14-day-old full-term female infant who presented with grunting and irritability to the emergency room and was diagnosed with GBS meningitis subsequently complicated with central diabetes insipidus and secondary hypopituitarism. Central diabetes insipidus should be ruled out in infants with complicated GBS meningitis.

Keyword

Group B streptococcus; Meningitis; Central diabetes insipidus; Newborn

MeSH Terms

Blindness, Cortical
Child
Deafness
Diabetes Insipidus, Neurogenic
Emergency Service, Hospital
Female
Fever
Humans
Hydrocephalus
Hypopituitarism*
Infant
Infant, Newborn
Intellectual Disability
Lethargy
Meningitis*
Quadriplegia
Seizures
Sepsis
Streptococcus
Tachypnea