J Korean Acad Periodontol.
1999 Sep;29(3):447-468.
Tissue Engineering with rhBMP-2: Bone Reconstruction in Implant Dentistry
- Affiliations
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- 1Temple University School of Dentistry, Department of Periodontology Director, Postgraduate Specialty Program in Periodontology Director, Laboratory for Applied Periodontal and Craniofacial Regeneration Diplomate, American Board of Periodontology, USA.
- 2University of Aachen Medical Center, Department of Prosthodontics Visiting Assistant Professor Temple University School of Dentistry, Department of Periodontology Research Fellow, Laboratory for Applied Periodontal & Craniofacial Regeneration, Germany.
- 3Temple University School of Dentistry Department of Periodontology and Postgraduate Specialty Program in Periodontology Associate Scientist, Laboratory for Applied Periodontal and Craniofacial Regeneration, USA.
- 4Department of Periodontology, College of Dentistry, Research Institute for Periodontal Regeneration, Yonsei University, Seoul, Korea.
Abstract
- The preclinical and clinical studies reviewed herein show that rhBMP-2 induces normal physiologic bone in relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone, and allows placement and osseointegration of dental implants. Clearly, the bone inducing capacity of rhBMP-2 is carrier and site dependent. rhBMP-2 in an absorbable collagen sponge carrier induces relevant bone formation in space providing defects. Space providing carries extends this possibility to nonspace providing sites. Notably, some ceramic and polymeric biomaterials may substantially interfere with rhBMP-2 induced osteogenesis.
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