J Korean Acad Prosthodont.  2010 Jul;48(3):202-208. 10.4047/jkap.2010.48.3.202.

Effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs

• Park CK
• Kim JE
• Shin JH
• Ryu JJ
• Huh JB
• Shin SW

• KMID: 2195556
• DOI: http://doi.org/10.4047/jkap.2010.48.3.202

Abstract

PURPOSE
This study was aimed to evaluate the effect of rhPMP-2 coated implants on alveolar ridge augmentation in dogs. Material and
METHODS
Six Beagle dogs were used in this study. Six 8.0 mm long anodized surface titanium implants were placed 5 mm into the mandibular alveolar ridge following 6 month of healing period after extraction. Each animal received three implants coated with rhBMP-2 and three uncoated control implants using the randomized split-mouth design. Radiographic examinations were undertaken i mmediately at implant placement (baseline), at weeks 4 and 8 after implant placement. The amount of bone augmentation was evaluated by measuring the distance from the uppermost point of the coverscrew to the marginal bone. Implant Stability Quotient (ISQ) values were measured i mmediately at implant placement and 8 weeks after implant placement. For the statistical analysis, Man-Whitney ranksum test and Wilcoxon signed rank test of SPSS 12.0 software were used (P = .05).
RESULTS
The BMP group exhibited radiographic vertical bone augmentation about 0.6 +/- 0.7 mm at 8 weeks later while controls showed bone loss about 0.4 +/- 0.6 mm. There was significant difference among the rhBMP-2 group and controls in bone level change (P < .05). The ISQ values were significantly higher in the BMP-2 group than the control group at 8 weeks later (P < .05), while there was no significant difference at surgery.
CONCLUSION
Within the limitation of this study, the rhBMP-2 coated on anodized implant could stimulate vertical alveolar bone augmentation, which may increase implant stability significantly on completely healed alveolar ridge.

Keyword

rhBMP-2; implant; Osseointegration; Implant stability; Bone augmentation

MeSH Terms

Alveolar Process
Alveolar Ridge Augmentation
Animals
Dogs
Osseointegration
Titanium
Titanium

Figure

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  Fig. 1. Design of experimental Implant (unit: mm). The experimental implants had internal connection, coronal microthread and macrothread.

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  Fig. 2. Diagram for installation site and depth on alveolar ridge of dog.

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  Fig. 3. Implant surgery. A: Drilling, B: Implant placement, C: ISQ value measuring, D: Suture, E: 1 week after surgery, F: 8 week after surgery.

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  Fig. 4. Measuring of marginal bone level.

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  Fig. 5. ISQ measuring device (Ostell Mentor).

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  Fig. 6. Periapical radiograph showing that implants coated with rhBMP-2 exhibited bone formation approaching the implant top, while there is no remarkable change of bone level on control implants.

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  Fig. 7. Radiographic bone gain by group and observation interval.

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  Fig. 8. Implant stability quotient (ISQ) value by group and observation interval (∗P < .05).

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  Fig. 9. Failure of osseointegration of implant. A: At surgery, B: There is radiolucent halo on leftmost implant at 4 week after surgery, C: The radiolucent halo enlarged along almost all implant surface at 8 week after surgery.

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  Fig. 10. Exposure of implant fixture. A: Exposure of 3 implants of control group, B: Exposure of one implant of BMP group.

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