Radiat Oncol J.  2016 Mar;34(1):34-44. 10.3857/roj.2016.34.1.34.

Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

• Yu JI
• Park HC
• Choi DH
• Noh JM
• Oh D
• Park JS
• Chang JH
• Kim ST
• Lee J
• Park SH
• Park JO
• Park YS
• Lim HY
• Kang WK

• KMID: 2316754
• DOI: http://doi.org/10.3857/roj.2016.34.1.34

Abstract

PURPOSE
A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer.
MATERIALS AND METHODS
Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated.
RESULTS
A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires.
CONCLUSION
Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer.

Keyword

Colorectal neoplasms; Radiotherapy; Induced hyperthermia; Quality of life; Pain

MeSH Terms

Colorectal Neoplasms*
Disease Progression
Fever*
Follow-Up Studies
Humans
Hyperthermia, Induced
Liver*
Neoplasm Metastasis*
Prospective Studies*
Quality of Life
Radiotherapy
Respiratory Insufficiency