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Efficacy of geriatric multidisciplinary oncology clinic in the surgical treatment decision-making process for frail elderly patients with colorectal cancer

Yang IJ, Oh HK, Lee J, Suh JW, Ahn HM, Shin HR, Kim JW, Kim JH, Song C, Choi JY, Kim DW, Kang SB

Purpose: Multidisciplinary care has become a cornerstone of colorectal cancer management. To evaluate the clinical efficacy of a geriatric multidisciplinary oncology clinic (GMOC), we analyzed the surgical treatment decision-making process...
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Factors associated with the risk of colorectal neoplasia in young adults under age 40

Kim I, Lee HH, Ko YJ, Chang HE, Cheung DY, Lee BI, Cho YS, Kim JI, Choi MG

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal...
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Cancer Risk Score Prediction Based on a Single-Nucleotide Polymorphism Network

Mahesworo B, Budiarto A, Hidayat AA, Pardamean B

Objectives: Genome-wide association studies (GWAS) are performed to study the associations between genetic variants with respect to certain phenotypic traits such as cancer. However, the method that is commonly used...
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Endoscopic diagnosis and treatment of early colorectal cancer

Hong SW, Byeon JS

Early colorectal cancer refers to cancer in the colorectum that is confined to the mucosa or submucosa and does not invade the muscularis propria, irrespective of lymph node or distant...
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Predicting stage ypT0–1N0 for nonradical management in patients with middle or low rectal cancer who undergo neoadjuvant chemoradiotherapy: a retrospective cohort study

Lee J, Yang IJ, Suh JW, Ahn Hm, Oh HK, Kim DW, Kim YH, Lee KH, Kang SB

Purpose: It is important to discover predictive factors that can identify rectal cancer patients who will respond well to neoadjuvant concurrent chemoradiotherapy (CCRT) to develop management strategies, preserve sphincter and...
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Gut Microbiota Alteration Influences Colorectal Cancer Metastasis to the Liver by Remodeling the Liver Immune Microenvironment

Yuan N, Li X, Wang M, Zhang Z, Qiao L, Gao Y, Xu X, Zhi J, Li Y, Li Z, Jia Y

Background/Aims:This study aimed to explore the effect of gut microbiota-regulated Kupffer cells (KCs) on colorectal cancer (CRC) liver metastasis. Methods: A series of in vivo and in vitro researches were showed...
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Association of Body Mass Index with Survival in Asian Patients with Colorectal Cancer

Lee S, Lee DH, Lee JH, Shin SJ, Lee HS, Park EJ, Baik SH, Lee KY, Kang J

Purpose The clinical significance of body mass index (BMI) on long-term outcomes has not been extensively investigated in Asian patients with colorectal cancer (CRC). This study aims to describe the association...
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Efficacy of a rehabilitation program using minor muscles in colorectal cancer patients with chemotherapy-induced neuropathy: preliminary study

Hong KS, Chung SS, Kim KH, Lee RA

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common reasons that colorectal cancer patients cannot maintain their routine chemotherapy schedules. Some medications are used for pain relief; however, the...
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Effects of the Advanced Practice Nurse-Led Psychoeducational Program for Colorectal Cancer Survivors

Kim HK, Yoo YS

Purpose: This study aimed to investigate the effects of an advanced practice nurse-led psychoeducational program on distress, anxiety, depression, coping with cancer (CWC), health promotion behavior (HPB), and quality of...
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Minimally invasive surgery for colorectal cancer, a look back to look forward: a personal history

Choi GS

While laparoscopic colonoscopy was reported by several surgeons in the early 1990s, laparoscopic colorectal surgery has been attempted sporadically since 1992 in Korea. Then, in 2000, the Korean Laparoscopic Colorectal...
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Characteristics and outcomes of colorectal cancer surgery by age in a tertiary center in Korea: a retrospective review

Lee TH, Choo JM, Kim JS, Shin SH, Kim JS, Baek SJ, Kwak JM, Kim J, Kim SH

Purpose: Colorectal cancer (CRC) occurs in all age groups, and the application of treatment may vary according to age. The study was designed to identify the characteristics of CRC by...
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Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer

Lee H, Lee HW, Park EJ, Kang J, Baik SH

Purpose: This study aimed to investigate the clinicopathologic features and survival in patients with both breast cancer (BrC) and colorectal cancer (CRC). Methods: Between 1996 and 2019, patients who were diagnosed...
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McKittrick-Wheelock Syndrome: A Case Series

Villanueva MEP, Onglao MAS, Tampo MMT, Lopez MPJ

McKittrick-Wheelock syndrome is a rare and life-threatening disease characterized by the triad of (1) chronic mucous diarrhea, (2) renal function impairment with hydroelectrolyte imbalance, and (3) a giant colorectal tumor....
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Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis

Kim Y, Cho NY, Kang GH

Background: Fusobacterium nucleatum has been identified to promote tumor progression in colorectal cancer (CRC). However, association between F. nucleatum and prognostic or clinicopathological features has been diverse among studies, which...
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Feasibility and safety of endoscopic submucosal dissection for lesions in proximity to a colonic diverticulum

Ikezawa N, Toyonaga T, Tanaka S, Yoshizaki T, Takao T, Abe H, Sakaguchi H, Tsuda K, Urakami S, Nakai T, Harada T, Miura K, Yamasaki T, Kostalas S, Morita Y, Kodama Y

Background/Aims: Endoscopic submucosal dissection (ESD) for diverticulum-associated colorectal lesions is generally contraindicated because of the high risk of perforation. Several studies on patients with such lesions treated with ESD have...
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Does computer-aided diagnostic endoscopy improve the detection of commonly missed polyps? A meta-analysis

Sivananthan A, Nazarian S, Ayaru L, Patel K, Ashrafian H, Darzi A, Patel N

Background/Aims: Colonoscopy is the gold standard diagnostic method for colorectal neoplasia, allowing detection and resection of adenomatous polyps; however, significant proportions of adenomas are missed. Computer-aided detection (CADe) systems in...
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Fasting Blood Glucose Variability and Unfavorable Trajectory Patterns Are Associated with the Risk of Colorectal Cancer

Jun H, Lee J, Lee HA, Kim SE, Shim KN, Jung HK, Jung SA, Moon CM

Background/Aims: The relationship between fasting blood glucose (FBG) variability and colorectal cancer (CRC) remains ill-defined. This study aimed to evaluate the association of FBG variability with CRC risk in the...
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Current status of robotic surgery for colorectal cancer: A review

Jung WB

The number of robot-assisted colorectal surgeries is increasing because these robotic devices afford surgeon-controlled, high-definition, and threedimensional vision during surgery and have sophisticated, angulated arms with remarkable ergonomics and a...
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Effect of chemotherapy on effect-site concentration of propofol for loss of consciousness in patients with colorectal cancer

Ki S, Cho Y, Choi Y, Lim S, Kim M, Lee J

Background: The depth of anesthesia is an essential factor in surgical prognosis. The neurotoxic effect of chemotherapeutic drugs affects the sensitivity to anesthetics. This study was conducted to determine whether...
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A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis

Zeng J, Xiao Xq, Zhou Zy

Purpose Emerging evidence has shown that SKP1-cullin-1-F-box-protein (SCF) E3 ligases contribute to the pathogenesis of different cancers by mediating the ubiquitination and degradation of tumor suppressors. However, the functions of SCF...
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