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Treatment response and disease progression

Holford N

This tutorial defines the concepts of disease progression in the context of clinical pharmacology. Disease progression describes the natural history of disease, such as pain, or biomarker of drug response,...
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Follow-Up of Stage A Carcinoma of the Prostate

Park JS, Lee SC

  • KMID: 2060276
  • Korean J Urol.
  • 1990 Jun;31(3):372-377.
The prognosis and proper treatment of Stage A carcinoma of the prostate remain unsettled. We report 19 patients with State A prostate cancer diagnosed between 1970 and 1988. Mean duration...
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Expression of c-erbB-2 and Distribution of S-100 Protein Positive Dendritic Cells in Squamous Cell Carcinoma of the Uterine Cervix

Shin JO, Choi SD, SunWoo JG, Bae DH, Kim DJ

  • KMID: 2083760
  • Korean J Gynecol Oncol Colposc.
  • 2000 Dec;11(4):397-403.
OBJECTIVE: The aim of this study was to assess the relationship between disease progression and expression of c-erbB-2 and S-100 protein positive dendritic cells in Cervical cancer. STUDY DESIGN: Tissues...
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Recurrence and Progression of Stage T1 Bladder Tumor after Intravesical Bacillus Calmette-Guerin(BCG) Therapy

Ha HS, Park CH, Kim CI

  • KMID: 2290122
  • Korean J Urol.
  • 1999 Oct;40(10):1279-1282.
PURPOSE: The management of patients with superficially invasive, stage T1N0M0 bladder cancer remains controversial. While some physicians advocated early cystectomy, others believe that with initial TURB and effective intravesical BCG,...
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Sequential CT Findings in Two Cases of Immunoglobulin G4-Related Lung Disease: Focused on Disease Progression

Lee DK, Ham SY

Immunoglobulin G4 (IgG4)-related lung disease has been actively studied over the past few years. Radiologic findings of IgG4-related lung disease vary among patients, but there are no long-term follow up...
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The Progression of Liver Fibrosis in Non-alcoholic Fatty Liver Disease

Kim MY

Understanding the pathogenesis of non-alcoholic steatohepatitis (NASH) and its fibrosis progression is still evolving. Nonetheless, current evidence suggests that mechanisms involved are very complex parallel processes with multiple metabolic factors....
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Association of Coronary Artery Disease and Pulse Pressure with Progression of Renal Disease

Kwon SK, Kim SH, Lee JI, Seo JW, Chang JW, Kim SB, Park JS

  • KMID: 1610151
  • Korean J Nephrol.
  • 2003 May;22(3):313-302.
BACKGROUND: Patients with end-stage renal disease have farther excess rate of coronary artery disease (CAD) than nonuremic population. There is a possibility that atherosclerosis may aggravate renal insufficiency, but it...
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The Expression of bcl-2, CD44 and p53 in Prostatic Adenocarcinoma

Lee BT, Park CH, Park KK

  • KMID: 2290279
  • Korean J Urol.
  • 1998 Dec;39(12):1229-1235.
PURPOSE: We evaluated the associations between the expression of bcl-2, CD44, p53 and tumor progression in prostate cancer. MATERIALS AND METHODS: Samples of prostatic tissue from 36 men with histologically...
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Clinical Features of Young-onset Parkinson's Disease

Cho EK, Lee MS

  • KMID: 2186001
  • J Korean Neurol Assoc.
  • 2001 Nov;19(6):579-584.
BACKGROUND: The term 'young-onset Parkinson's disease (YOPD)' refers to patients who have developed parkison-ian symptoms or signs between the ages of 21 and 40, and the term 'old onset Parkinson's...
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The Use of MR Perfusion Imaging in the Evaluation of Tumor Progression in Gliomas

Snelling B, Shah AH, Buttrick S, Benveniste R

OBJECTIVE: Diagnosing tumor progression and pseudoprogression remains challenging for many clinicians. Accurate recognition of these findings remains paramount given necessity of prompt treatment. However, no consensus has been reached on...
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Clinical Predictors of Disease Progression in New-Onset Urticaria

Lee BI, Lee JH, Park YM, Lee JY

  • KMID: 2246226
  • Korean J Dermatol.
  • 2015 Feb;53(2):119-126.
BACKGROUND: Chronic spontaneous urticaria (CSU) is considered a different disease entity from acute urticaria in relation to its pathogenesis, despite both disease types having similar clinical manifestations that include wheals,...
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A Case of Achieving Partial Remission with the Combination of Sorafenib and Nivolumab in a Patient with Hepatocellular Carcinoma Showing Disease Progression after Nivolumab Therapy

Hwang SY, Lee SM, Im JW, Jeon KJ, Choi CW, Kim KS, Jeon W

Sorafenib is a well-known approved systemic therapeutic agent used in patients with advanced hepatocellular carcinoma (HCC). Regorafenib and nivolumab are approved as second-line therapeutic drugs in patients showing disease progression...
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The Role of Axonopathy in Parkinson's Disease

O'Malley K

New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since...
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Factors for Computed Tomography Assessed Progression of Lesions in Patients with Traumatic Subarachnoid Hemorrhage

Choi DS, Kim GT

  • KMID: 2332713
  • J Korean Soc Emerg Med.
  • 2010 Apr;21(2):207-217.
PURPOSE: Traumatic subarachnoid hemorrhage (TSAH) is frequently found after traumatic brain injury (TBI) and its presence is a powerful predictor for the computed tomography (CT) assessed progression of intracranial lesions....
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Clinicoepidemiological Features of Asymptomatic Moyamoya Disease in Adult Patients

Yang J, Hong JC, Oh CW, Kwon OK, Hwang G, Kim JE, Kang HS, Cho WS, Kim T, Moon JU, Ahn SY, Kim JH, Bang JS

OBJECTIVE: The aim of this study was to document the natural course of asymptomatic adult moyamoya disease (MMD) and the factors related to disease progression to aid in treatment decisions. MATERIALS...
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Disease Progression in Chronic Hepatitis B Patients under Long-Term Antiviral Therapy

Moon JC, Kim SH, Kim IH, Lee CH, Kim SW, Lee SO, Lee ST, Kim DG

BACKGROUND/AIMS: We investigated factors associated with the disease progression and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients during long-term oral nucleos(t)ide analog (NA) therapy. METHODS: This retrospective...
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Olfaction and Neurodegenerative Disease

Kim HY

Olfactory dysfunction is an early and common symptom of many neurodegenerative diseases, particularly of Parkinson's disease, Alzheimer's disease, and mild cognitive impairment that heralds progression to dementia. Olfactory impairment is...
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How do we manage high-grade T1 bladder cancer? Conservative or aggressive therapy?

Yun SJ, Kim SK, Kim WJ

High-grade T1 bladder cancer has a poor prognosis due to a higher incidence of recurrence and progression than other nonmuscle invasive bladder cancer; thus patients with high-grade T1 have to...
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Rapid Progression of Gliomatosis Cerebri to Secondary Glioblastoma, Factors That Affect the Progression Rate: A Case Report

Kim HK, Yu IK, Kim SM, Kim JH, Lee SH, Lee SY

Glioblastomas may develop de novo or through progression from low-grade or anaplastic astrocytomas. The term ‘primary glioblastoma’ refers to a glioblastoma that lacks a precursor lesion and has a clinical...
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The Functional Changes of Cognitive and Non-Cognitive Domains in the Progression of Alzheimers Disease

Kim TY, Lee SC, Park KW, Yoo BG

  • KMID: 1516082
  • J Korean Geriatr Soc.
  • 2003 Mar;7(1):47-54.
BACKGROUND: There were many studies about the changes of cognitive or non-cognitive domain and behavioral and psychological symptoms with the progression of Alzheimer's disease. But they assessed the changes individually...
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