Exp Neurobiol.  2010 Dec;19(3):115-119. 10.5607/en.2010.19.3.115.

The Role of Axonopathy in Parkinson's Disease

• O'Malley K

• KMID: 1460755
• DOI: http://doi.org/10.5607/en.2010.19.3.115

Abstract

New genetic and environmental studies of Parkinson's disease have revealed early problems in synaptic function and connectivity indicating that axonal impairment may be an important hallmark in this disorder. Since many studies suggest that axonal dysfunction precedes cell body loss, it is critical to target axons with treatments aimed at preserving "connectivity" as well as to develop and verify "biomarkers" with which to assess disease progression and drug efficacy.

Keyword

axon transport; mitochondria; Wallerian degeneration; MPTP

MeSH Terms

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Axons
Disease Progression
Mitochondria
Parkinson Disease
Wallerian Degeneration
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine