Nat Prod Sci.  2015 Sep;21(3):205-209. 10.0000/nps.2015.21.3.205.

Anti-inflammatory Activity of Fucoidan with Blocking NF-kappaB and STAT1 in Human Keratinocytes Cells

• Ryu MJ
• Chung HS

• KMID: 2312897
• DOI: http://doi.org/10.0000/nps.2015.21.3.205

Abstract

Fucoidan, a sulfated polysaccharide is found in several types of edible brown algae. It has shown numerous biological activities; however, the molecular mechanisms on the activity against atopic dermatitis have not been reported yet. We now examined the effects of fucoidan on chemokine production co-induced by TNF-alpha/IFN-gamma, and the possible mechanisms underlying these biological effects. Our data showed that fucoidan inhibited the TNF-alpha/IFN-gamma-induced production of thymus and activation-regulated chemokine (TARC) and macrophagederived chemokine (MDC) mRNA in human keratinocytes HaCaT cells. Also, fucoidan suppressed phosphorylation of nuclear factor kappa B (NF-kappaB) and activation of signal transducer and activator of transcription (STAT)1 in a dose-dependent manner. In addition, fucoidan significantly inhibited activation of extracellular-signal-regulated kinases (ERK) phosphorylation. These data indicate that fucoidan shows anti-inflammatory effects by suppressing the expression of TNF-alpha/IFN-gamma-induced chemokines by blocking NF-kappaB, STAT1, and ERK1/2 activation, suggestive of as used as a therapeutic application in inflammatory skin diseases, such as atopic dermatitis.

Keyword

Fucoidan; Anti-inflammation; Chemokine; Nuclear factor-kappa B; Signal transducer and activator of transcription 1

MeSH Terms

Chemokine CCL17
Chemokines
Dermatitis, Atopic
Humans*
Keratinocytes*
NF-kappa B*
Phaeophyta
Phosphorylation
Phosphotransferases
RNA, Messenger
Skin Diseases
STAT1 Transcription Factor
Transducers
Chemokine CCL17
Chemokines
NF-kappa B
Phosphotransferases
RNA, Messenger
STAT1 Transcription Factor