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Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy

Nakata J, Hirota T, Umemura H, Nakagawa T, Kando N, Futamura M, Nakamura Y, Ito K

BACKGROUND: Atopic dermatitis (AD) in infants is often related to food allergies (FA). The beneficial effects of lactic acid bacteria towards allergic diseases have been reported, but there are few...
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Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis

Matsuda-Hirose H, Yamate T, Goto M, Katoh A, Kouji H, Yamamoto Y, Sakai T, Uemura N, Kobayashi , Hatano Y

BACKGROUND: The canonical Wnt/β-catenin signaling pathway is a fundamental regulatory system involved in various biological events. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic AMP response...
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Investigation of Immune-Regulatory Effects of Mageumsan Hot Spring via Protein Microarray In Vitro

Hahn HJ, Kim JS, Kim YH, Lee YB, Yu DS, Kim JW

BACKGROUND: Empirical evidences for efficacy of hot spring (HS) water in inflammatory skin disorders have not been substantiated with sufficient, immunological “hard evidence”. Mageumsan HS water, characterized by its weakly-alkaline...
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Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid

Joo YA, Chung H, Yoon S, Park JI, Lee JE, Myung CH, Hwang JS

Atopic dermatitis (AD) results from gene and environment interactions that lead to a range of immunological abnormalities and breakdown of the skin barrier. Protease-activated receptor 2 (PAR2) belongs to a...
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Anti-inflammatory Activity of Fucoidan with Blocking NF-kappaB and STAT1 in Human Keratinocytes Cells

Ryu MJ, Chung HS

Fucoidan, a sulfated polysaccharide is found in several types of edible brown algae. It has shown numerous biological activities; however, the molecular mechanisms on the activity against atopic dermatitis have...
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Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes

Yano C, Saeki H, Komine M, Kagami S, Tsunemi Y, Ohtsuki M, Nakagawa H

BACKGROUND: CC chemokine ligand 17 (CCL17) and CCL22 are the functional ligands for CCR4. We previously reported that inhibitors of nuclear factor-kappa B and p38 mitogen-activated protein kinase (p38 MAPK),...
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Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes

Kang GJ, Han SC, Ock JW, Kang HK, Yoo ES

  • KMID: 1502516
  • Biomol Ther.
  • 2013 Mar;21(2):138-145.
Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than...
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Elevated Serum Levels of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine and Their Relationships with Eosinophilic Inflammatory Markers in Children with Allergic Diseases

  • KMID: 2299451
  • Korean J Asthma Allergy Clin Immunol.
  • 2012 Dec;32(4):216-223.
BACKGROUND: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators, but the role of...
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The Relationship between Atopic Dermatitis, Thymus and Activation-Regulated Chemokine/CCL17, Quality of Life, and Attention Deficit-Hyperactivity Disorder in Preschool Children

Park DH, Chung SH, Shim JW, Kim DS, Jung HL, Park MS, Shim JY

  • KMID: 2315131
  • Pediatr Allergy Respir Dis.
  • 2011 Sep;21(3):215-225.
PURPOSE: Atopic dermatitis may impair quality of life and lead to attention deficit-hyperactivity disorder (ADHD). Thymus and activation-regulated chemokine (TARC)/CCL17 may serve as a new biomarker for atopic dermatitis. We...
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Increased Expression and Role of Thymic Stromal Lymphopoietin in Nasal Polyposis

Kimura S, Pawankar R, Mori S, Nonaka M, Masuno S, Yagi T, Okubo K

PURPOSE: Nasal polyposis is a chronic inflammatory disease of the upper airways often associated with asthma and characterized by markedly increased numbers of eosinophils, Th2 type lymphocytes, fibroblasts, goblet cells...
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Transforming growth factor-beta promoted vascular endothelial growth factor release by human lung fibroblasts

Park SU, Shin JH, Shim JW, Kim DS, Jung HL, Park MS, Shim JY

PURPOSE: The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal...
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Expression of TARC in Nasal Epithelial Cells by IL-4/IL-13 and TNF-alpha in Allergic Rhinitis

Lee KH, Kim SW, Shin SY, Cho JS

  • KMID: 2131937
  • J Rhinol.
  • 2008 Nov;15(2):129-133.
BACKGROUND: Thymus and Activation-Regulated Chemokine (TARC) is a highly specific ligand for CCR4 expressed in Th2 lymphocytes. Local production of TARC may play an important role in the induction and...
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Correlation between Different Chemokines Induced by Specific Allergens in Atopic Dermatitis

Chang YS, Jeoung EY, Kim CR, Yum MK, Lee HB, Oh JW

  • KMID: 2314574
  • Pediatr Allergy Respir Dis.
  • 2007 Dec;17(4):404-411.
PURPOSE:Many patients with atopic dermatitis have shown different responses to treatment or different prognosis dependenting on the kinds of offending allergens. We attempted to evaluate the difference of mechanism in...
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Increased Serum Thymus and Activation-regulated Chemokine (TARC) Levels in Children with Atopic Dermatitis

Song TW, Kwon BC, Choi SY, Shin YH, Lee KE, Yang HS, Kim KW, Kim ES, Sohn MH, Kim KE

  • KMID: 2314384
  • Pediatr Allergy Respir Dis.
  • 2005 Sep;15(3):250-256.
PURPOSE: Thymus and activation-regulated chemokine (TARC) is responsible for the trafficking of Th2 lymphocytes into sites of allergic inflammation. We tested whether TARC is a useful marker for childhood atopic...
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Serum Levels of Type 2 Chemokines in Lepromatous Leprosy Patients

Lew W, Nakamura K, Tada Y, Kwahck H, Chang SK, Tamaki K

BACKGROUND: The type 2 deviated immunological state is predominant in lepromatous leprosy. Erythema nodosum leprosum (ENL) is an immune-complex mediated reaction that typically occurs in lepromatous leprosy. To date, the...
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