Asia Pac Allergy.  2019 Apr;9(2):e18. 10.5415/apallergy.2019.9.e18.

Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy

• Nakata J
• Hirota T
• Umemura H
• Nakagawa T
• Kando N
• Futamura M
• Nakamura Y
• Ito K

• KMID: 2444118
• DOI: http://doi.org/10.5415/apallergy.2019.9.e18

Abstract

BACKGROUND
Atopic dermatitis (AD) in infants is often related to food allergies (FA). The beneficial effects of lactic acid bacteria towards allergic diseases have been reported, but there are few reports on their effect and preferable dosages on AD in young children with concomitant FA.
OBJECTIVE
To examine additional effects of two different dose of paraprobiotic Lactobacillus acidophilus L-92 (L-92) on the clinical treatment in young children afflicted by AD with diagnosed or suspected FA.
METHODS
Fifty-nine AD young children from 10 months to 3 years old, with FA or who had not started to ingest specific food(s) because of high specific IgE levels, were recruited and randomly allocated into L-92 group (daily intake of 20 mg L-92/day) and placebo group. Participants were given test sample with conventional treatment for AD over a 24-week period. The severity of eczema was evaluated using SCORing Atopic Dermatitis (SCORAD) index before intervention, and at 4, 12, and 24 weeks after intervention.
RESULTS
After 24 weeks of intervention, a significant decrease in SCORAD was observed only in the L-92 group when compared with the baseline values. Significant decreases in thymus and activation-regulated chemokine (TARC) and total IgE were also detected 24 weeks after intake in the L-92 group compared with the placebo group.
CONCLUSION
It was suggested that intake of sufficient amounts of L-92 works as an adjunctive treatment of young children afflicted by AD with diagnosed or suspected FA.

Keyword

Lactobacillus acidophilus; Atopic dermatitis; Food sensitivity

MeSH Terms

Bacteria
Chemokine CCL17
Child*
Dermatitis, Atopic*
Eczema
Food Hypersensitivity*
Humans
Immunoglobulin E
Infant
Lactic Acid
Lactobacillus acidophilus*
Lactobacillus*
Chemokine CCL17
Immunoglobulin E
Lactic Acid