Korean J Psychopharmacol.  2006 May;17(3):253-262.

The Function of 5-HT(1A) Receptor and Pharmacotherapy

• Kim W
• Bahk WM

Abstract

5-HT(1A) receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT(1A) autoreceptor desensitization plays an important role in the treatment of depression and anxiety. 5-HT(1A) receptor stimulation may also mediate the neurogenesis of prefrontal cortex and hippocampus. The 5-HT(1A) agonism has an important meaning in the treatment of schizophrenia. Most atyptical antipsychotics have the property of 5-HT(2A) antagonist, and some have that of 5-HT(1A) agonist. In the various regions of brain, 5-HT(1A) and 5-HT(2A) have the functionally antagonistic properties. Recently, 5-HT(1A) receptor-related agents have been investigated in the treatment of acute ischemic stroke and Alzheimer's disease. Therefore, the further understanding about the 5-HT(1A) receptors in the brain functions will provide the development of future drugs and the advancement of psychopharmacology.

Keyword

5-HT(1A) receptor; Serotonin; Depression; Anxiety; Schizophrenia; Psychopharmacology

MeSH Terms

Alzheimer Disease
Antipsychotic Agents
Anxiety
Autoreceptors
Brain
Depression
Drug Therapy*
Felodipine
Hippocampus
Neurogenesis
Prefrontal Cortex
Psychopharmacology
Receptor, Serotonin, 5-HT1A*
Schizophrenia
Serotonin
Serotonin Uptake Inhibitors
Stroke
Antipsychotic Agents
Autoreceptors
Felodipine
Receptor, Serotonin, 5-HT1A
Serotonin
Serotonin Uptake Inhibitors