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Aripiprazole-induced Hepatitis: A Case Report

Castanheira L, Fernandes , Levy P, Coentre R

Aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-HT1A receptors. It is used in the treatment of schizophrenia and...
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Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling

Chang KJ, Chen YJ, Chung JY, Lin CC, Liu YP

OBJECTIVE: Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present...
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Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling

Tai YM, Ko CY, Lin CC, Wan YY, Chung JY, Liu YP

OBJECTIVE: Central 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role is not clearly defined in developmentally social deprived (isolation rearing, IR) rats featured...
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Association of Serotonin 1A Receptor Polymorphism with Variation in Health-Related Quality of Life in Korean Hemodialysis Patients

Park HC, Park S, Choi HY, Lee JE, Park HY, Kim SH, Ha SK, Seok JH

OBJECTIVE: Hemodialysis patients may have psychological distress and reduced quality of life (QoL) related to chronic physical health problems. Genetic polymorphisms associated with reduced QoL in hemodialysis patients. The aim...
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Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder

Watanabe T, Ishiguro S, Aoki A, Ueda M, Hayashi Y, Akiyama K, Kato K, Shimoda K

OBJECTIVE: Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for...
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Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation

Lee SJ, Kim TW, Park HK, Yoon S, You AH, Moon EJ, Shin DH, Cho H

  • KMID: 2309840
  • Int Neurourol J.
  • 2016 May;20(Suppl 1):S57-S64.
PURPOSE: Stress during pregnancy is a risk factor for the development of anxiety-related disorders in offspring later in life. The effects of treadmill exercise on anxiety-like behaviors and hippocampal cell...
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Vilazodone for the Treatment of Depression: An Update

Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU

Vilazodone is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitor and 5-HT(1A) receptor partial agonist profile, so it has been regarded as a serotonin partial agonist-reuptake inhibitor (SPARI)....
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Vilazodone for the Treatment of Major Depressive Disorder: Focusing on Its Clinical Studies and Mechanism of Action

Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU

We tried to review and update clinical and preclinical studies evaluating vilazodone's role as an antidepressant for patients with major depressive disorder (MDD). In terms of its mechanism of actions,...
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Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in Rats

Kim TW, Lim BV, Baek D, Ryu DS, Seo JH

PURPOSE: Stress is associated with depression, which induces many psychiatric disorders. Serotonin, also known as 5-hydroxy-tryptamine (5-HT), acts as a biochemical messenger and regulator in the brain. It also mediates...
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Nonresponders to Daily Paroxetine and Another SSRI in Men With Lifelong Premature Ejaculation: A Pharmacokinetic Dose-Escalation Study for a Rare Phenomenon

Janssen PK, Touw D, Schweitzer DH, Waldinger

PURPOSE: Nonresponse to any selective serotonin reuptake inhibitor (SSRI) treatment is rare. In this study, we aimed to investigate ejaculation delay nonresponse to paroxetine treatment in men with lifelong premature...
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Long-term Efficacy and Tolerability of Perospirone for Young Help-seeking People at Clinical High Risk: a Preliminary Open Trial

Tsujino N, Nemoto T, Morita K, Katagiri N, Ito S, Mizuno M

  • KMID: 2171146
  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):132-136.
OBJECTIVE: Interest in the "at-risk mental state" (ARMS) for psychosis has increased because early intervention is expected to delay or prevent the onset of schizophrenia. However, the optimum intervention strategy...
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No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression

Serretti A, Fabbri C, Pellegrini S, Porcelli S, Politi P, Bellino S, Menchetti , Mariotti V, Demi C, Martinelli V, Cappucciati M, Bozzatello P, Brignolo E, Brambilla , Pae CU, Balestrieri M, De Ronchi

  • KMID: 2316266
  • Psychiatry Investig.
  • 2013 Jun;10(2):180-189.
OBJECTIVE: Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been...
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Tardive Dyskinesia: Treatment with Aripiprazole

Kang NR, Kim MD

  • KMID: 2171279
  • Clin Psychopharmacol Neurosci.
  • 2011 Apr;9(1):1-8.
Tardive dyskinesia is characterized by choreiform movements, or rhythmic abnormal involuntary movements of the face, mouth, tongue, trunk, and limbs. It is frequently associated with the use of neuroleptic medications....
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Association Study between 5-HT1A Receptor Gene C(-1019)G Polymorphism and Panic Disorder in a Korean Population

Choi WS, Lee BH, Yang JC, Kim YK

  • KMID: 2315880
  • Psychiatry Investig.
  • 2010 Jun;7(2):141-146.
OBJECTIVE: Serotonergic dysfunction is quite evident in panic disorder. We investigated whether the C(-1019)G polymorphism of 5-HT1A receptor gene may play a role in the pathogenesis of panic disorder in...
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Regional Distribution of 5-HT 1A, 1B, and 1D Receptors in Rat Vestibular Nuclei (Vn) and Inner Ear

Ahn SK, Balaban CD

  • KMID: 2328942
  • J Korean Bal Soc.
  • 2008 Dec;7(2):228-228.
Migraine and anxiety disorders are frequently co-morbid with balance disorders. Potential mechanisms for migrainous vertigo include sites of action of 5-HT (serotonin) 1B and 1D receptor agonists such as rizatriptan,...
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Role of 5-HT1A Receptors in Learning and Memory

Kim JW

  • KMID: 2287029
  • Korean J Psychopharmacol.
  • 2007 Sep;18(5):271-279.
Growing evidence indicates that the serotonin system is important in learning and memory. In particular, several preclinical and clinical studies suggest that modulating the 5-HT1A receptor can influence learning and...
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Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function

Kim JG, Kim MS, Lee S, Kim GT, Lee JD, Kim DG

  • KMID: 2285334
  • Korean J Physiol Pharmacol.
  • 2007 Jun;11(3):113-119.
Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a...
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Serotonin (5-HT) Receptor Subtypes Mediate Regulation of Neuromodulin Secretion in Rat Hypothalamic Neurons

Chin C, Kim SI

  • KMID: 2166259
  • Genomics Inform.
  • 2007 Jun;5(2):77-82.
Serotonin (5-HT), the endogenous nonselective 5-HT receptor agonist, activates the inositol -1,4,5- triphosphate / calcium (InsP3/Ca2+) signaling pathway and exerts both stimulatory and inhibitory actions on cAMP production and neuromodulin...
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Outlook of Future Serotonergic Drugs and Their Clinical Usefulness: Focused on Schizophrenia and Depression

Kim YK

  • KMID: 2287362
  • Korean J Psychopharmacol.
  • 2006 May;17(3):273-282.
Serotonin has been implicated in the etiology and pathophysiology of mental illness such as depression, schizophrenia, anxiety disorder, eating disorder, obsessive compulsive disorder, and panic disorder. Many current used treatments...
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The Function of 5-HT(1A) Receptor and Pharmacotherapy

Kim W, Bahk WM

  • KMID: 2287360
  • Korean J Psychopharmacol.
  • 2006 May;17(3):253-262.
5-HT(1A) receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT(1A)...
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