Clin Psychopharmacol Neurosci.  2011 Apr;9(1):1-8.

Tardive Dyskinesia: Treatment with Aripiprazole

• Kang NR
• Kim MD

Abstract

Tardive dyskinesia is characterized by choreiform movements, or rhythmic abnormal involuntary movements of the face, mouth, tongue, trunk, and limbs. It is frequently associated with the use of neuroleptic medications. The choreiform movements are irreversible in some patients, even after the drug is withdrawn. Although no reliable treatment for tardive dyskinesia exists, atypical antipsychotics are associated with a significantly lower incidence of tardive dyskinesia than typical antipsychotics. Moreover, recent reports suggest that atypical antipsychotics may have a beneficial effect on tardive dyskinesia remission. Until recently, evidence for the effectiveness of aripiprazole on tardive dyskinesia has been mixed. Aripiprazole has a unique mechanism of action and has various effects in tardive dyskinesia. The drug acts as a partial D2 receptor agonist that can stabilize D2 up-regulation, and as a partial 5-HT1A receptor agonist and a 5-HT2A receptor antagonist, and can increase the release of dopamine in the striatum.

Keyword

Aripiprazole; Tardive dyskinesia

MeSH Terms

Antipsychotic Agents
Chorea
Dopamine
Dyskinesias
Extremities
Humans
Incidence
Mouth
Movement Disorders
Piperazines
Quinolones
Receptor, Serotonin, 5-HT1A
Receptor, Serotonin, 5-HT2A
Tongue
Up-Regulation
Aripiprazole
Antipsychotic Agents
Dopamine
Piperazines
Quinolones
Receptor, Serotonin, 5-HT1A
Receptor, Serotonin, 5-HT2A