J Korean Soc Biol Psychiatry.  1999 Jul;6(1):89-95.

Association of Tardive Dyskinesia with Cognitive Deficit in Schizophrenia

• Jang TS
• Oh BH
• Cheon JS

Abstract

To understand a mechanism of underlying cognitive deficit in schizophrenia, the risk factors, cognitive function, blood dopamine concentrations and glutamate dehydrogenase activities of male schizophrenics with tardive dyskinesia(N=30) were compared with those of schizophrenics without tardive dyskinesia(N=30). The result were as following ; 1) The age, duration of illness and duration of medication were significantly more in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.005, p<0.0001, p<0.0001). 2)The scores of MMSE, TIQ, VIQ and PIQ were significantly lower in schizophrenics with tradive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.0001). 3) plasma dopamine concentrations were tended to be higher, and serum glutamate dehydrogenase activities were tended to be lower in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia. 4) The cognitive deficit seemed to be negatively correlated with duration of illness and duration of illness and duration of medication(respectively gamma=-0.496, gamma=-0.615).

MeSH Terms

Dopamine
Dyskinesias
Glutamate Dehydrogenase
Humans
Male
Movement Disorders*
Plasma
Risk Factors
Schizophrenia*
Dopamine
Glutamate Dehydrogenase