Cognitive Dysfunctions in Positive and Negative Schizophrenic Patients with or without Tardive Dyskinesia

Yu, Bum Hee; Kim, Ji Hae; Bae, Joo Mi; Lee, Kang Uk; Woo, Jong Min; Kim, S Peter

Abstract

OBJECTIVE
The goal of this study was to examine cognitive dysfunctions in positive and negative schizophrenic patients and investigate the effect of tardive dyskinesia on cognitive dysfunctions in them.
METHODS
Thirty two schizophrenic patients with tardive dyskinesia and thirty two schizophrenic patients without tardive dyskinesia as a control group were selected some psychiatric inpatients at a lunatic asylum and the cognitive dysfunctions of these patients were assessd with some neuropsychological tests including KWIS test, Grooved Pegboard test, Trail making test A and B, Wisconsin card sorting test, and Wechsler memory scale test. From these patients, we classified eighteen schizophrenic patients as a positive syndrome group and twenty five patients as a negative syndrome group with positive and negative syndrome scale and compared the results of neuropsychological tests between these two groups.
RESULTS
Patients without tardivc dyskinesia showed better performances than those with tardive dyskinesia on picture completion subtest of KWIS. Positive schizophrenic patients showed better performances than negative schizophrenic patients on comprehension subtest of KWIS and trail making test A.
CONCLUSION
Negative schizophrenic patients showed frontal lobe dyfunction and more memory impairment than positive schizophrenic patients. In conclusion, negative syndrome of schizophrenia is significantly associated with cognitive dysfunctions although tardive dyskinesia is not.