Clin Psychopharmacol Neurosci.  2024 Nov;22(4):688-696. 10.9758/cpn.24.1185.

Successful Electroconvulsive Therapy for Tardive Dyskinesia and Tardive Dystonia Refractory to Valbenazine Treatment: A Case Report and Narrative Literature Review

• Irinaka K
• Itoh Y
• Yoshizawa K
• Ogasawara M
• Ayabe N
• Mishima K
• Takeshima M

• KMID: 2562281
• DOI: http://doi.org/10.9758/cpn.24.1185

Abstract

Tardive dyskinesia and dystonia are intractable extrapyramidal symptoms caused by the blockade of dopamine receptors by antipsychotic drugs. In addition to the reduction or discontinuation of the causative drug, valbenazine for tardive dyskinesia and botulinum toxin for tardive dystonia have been reported to be effective. However, their efficacy has not been fully demonstrated. In this study, we report the case of a female patient with bipolar disorder, valbenazine-resistant tardive dystonia, and tardive dyskinesia who achieved improvement in extrapyramidal symptoms with electroconvulsive therapy. Additionally, we conducted a narrative literature review on the safety and efficacy of electroconvulsive therapy for tardive dyskinesia and dystonia.

Keyword

Electroconvulsive therapy; Tardive dyskinesia; Tardive dystonia; Valbenazine