- Role of 5-HT1A Receptors in Learning and Memory
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Kim JW
- KMID: 2287029
- Korean J Psychopharmacol.
- 2007 Sep;18(5):271-279.
Growing evidence indicates that the serotonin system is important in learning and memory. In particular, several preclinical and clinical studies suggest that modulating the 5-HT1A receptor can influence learning and... -
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- Effects of Paroxetine on the Desensitization of 5-HT(1A) and 5-HT(1B) Receptors
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Park HY
- KMID: 1964094
- Ewha Med J.
- 2004 Sep;27(2):113-118.
- doi: 10.12771/emj.2004.27.2.113
No abstract available in English. -
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- Serotonin (5-HT) Receptor Subtypes Mediate Regulation of Neuromodulin Secretion in Rat Hypothalamic Neurons
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Chin C, Kim SI
- KMID: 2166259
- Genomics Inform.
- 2007 Jun;5(2):77-82.
Serotonin (5-HT), the endogenous nonselective 5-HT receptor agonist, activates the inositol -1,4,5- triphosphate / calcium (InsP3/Ca2+) signaling pathway and exerts both stimulatory and inhibitory actions on cAMP production and neuromodulin... -
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- Tardive Dyskinesia: Treatment with Aripiprazole
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Kang NR, Kim MD
- KMID: 2171279
- Clin Psychopharmacol Neurosci.
- 2011 Apr;9(1):1-8.
Tardive dyskinesia is characterized by choreiform movements, or rhythmic abnormal involuntary movements of the face, mouth, tongue, trunk, and limbs. It is frequently associated with the use of neuroleptic medications.... -
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- Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats
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Lee S, Zhang TY, Kim GT, Kim HS, Lee JD, Jahng JW, Kim DG
- KMID: 1615195
- Korean J Physiol Pharmacol.
- 2002 Dec;6(6):293-297.
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50 microgram/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later... -
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- Association Study between 5-HT1A Receptor Gene C(-1019)G Polymorphism and Panic Disorder in a Korean Population
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Choi WS, Lee BH, Yang JC, Kim YK
- KMID: 2315880
- Psychiatry Investig.
- 2010 Jun;7(2):141-146.
OBJECTIVE: Serotonergic dysfunction is quite evident in panic disorder. We investigated whether the C(-1019)G polymorphism of 5-HT1A receptor gene may play a role in the pathogenesis of panic disorder in... -
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- Evaluation of the Role of 5-Hydroxytryptamine Receptor Subtypes in the Regulation of Nociceptive Transmission in the Rat Spinal Cord
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Jeong CY, Bae HB, Park HC, Choi JI, Yoon MH
- KMID: 2032603
- Korean J Anesthesiol.
- 2004 Dec;47(6):856-861.
- doi: 10.4097/kjae.2004.47.6.856
BACKGROUND: Spinal 5-hydroxytryptamine (5-HT) has been shown to display an antinociceptive effect, which is mediated by 5-HT receptors. Previous studies have revealed the presence of at least four types of... -
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- Regional Distribution of 5-HT 1A, 1B, and 1D Receptors in Rat Vestibular Nuclei (Vn) and Inner Ear
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Ahn SK, Balaban CD
- KMID: 2328942
- J Korean Bal Soc.
- 2008 Dec;7(2):228-228.
Migraine and anxiety disorders are frequently co-morbid with balance disorders. Potential mechanisms for migrainous vertigo include sites of action of 5-HT (serotonin) 1B and 1D receptor agonists such as rizatriptan,... -
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- The Function of 5-HT(1A) Receptor and Pharmacotherapy
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Kim W, Bahk WM
- KMID: 2287360
- Korean J Psychopharmacol.
- 2006 May;17(3):253-262.
5-HT(1A) receptor is implicated in the pathogenesis and the therapeutic mechanism of various psychiatric disorders. Especially, the mechanism of action of selective serotonin reuptake inhibitors (SSRIs) was hypothesized that 5-HT(1A)... -
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- Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder
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Watanabe T, Ishiguro S, Aoki A, Ueda M, Hayashi Y, Akiyama K, Kato K, Shimoda K
- KMID: 2365017
- Psychiatry Investig.
- 2017 Jan;14(1):86-92.
- doi: 10.4306/pi.2017.14.1.86
OBJECTIVE: Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for... -
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- Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling
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Chang KJ, Chen YJ, Chung JY, Lin CC, Liu YP
- KMID: 2425512
- Psychiatry Investig.
- 2018 Oct;15(10):1000-1006.
- doi: 10.30773/pi.2018.08.21.2
OBJECTIVE: Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present... -
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- Outlook of Future Serotonergic Drugs and Their Clinical Usefulness: Focused on Schizophrenia and Depression
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Kim YK
- KMID: 2287362
- Korean J Psychopharmacol.
- 2006 May;17(3):273-282.
Serotonin has been implicated in the etiology and pathophysiology of mental illness such as depression, schizophrenia, anxiety disorder, eating disorder, obsessive compulsive disorder, and panic disorder. Many current used treatments... -
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- Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling
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Tai YM, Ko CY, Lin CC, Wan YY, Chung JY, Liu YP
- KMID: 2409429
- Psychiatry Investig.
- 2018 Feb;15(2):193-199.
- doi: 10.30773/pi.2017.05.14.2
OBJECTIVE: Central 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role is not clearly defined in developmentally social deprived (isolation rearing, IR) rats featured... -
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- Evidence for Peripheral Effect of Serotonin on Ejaculatory Response
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Paick JS, Park DW, Son H, Lee SH, Kim SW
- KMID: 1859356
- Korean J Androl.
- 2001 Dec;19(3):163-171.
PURPOSE: Although serotonin (5-HT) has been implicated in central control of sexual desire, erection and ejaculation, its peripheral effect has been poorly studied. Here, we investigated the peripheral effects of... -
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- Serotonin 1A Receptor Agonist(8 OH DPAT) Reduces Tissue Lesion Volume in the Rat Middle Cerebral Artery Occlusion Model of Ischemia
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Yoon DH, Kim YS, Young W
- KMID: 2067415
- J Korean Neurosurg Soc.
- 1996 Jul;25(7):1352-1363.
We studied the effectiveness of serotonin 1a agonist(8 OH DPAT) on the 24 hour ionic lesion volume produced by permanent occlusion of the middle cerebral artery(MCAo) in rats. A 4-hour... -
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- Efficacy of Buspirone Hydrochloride in Migraineurs with Anxiety: a Randomized Double Blind, Parallel Group, Placebo-controlled Study
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Lee ST, Kim M
- KMID: 2343080
- J Korean Neurol Assoc.
- 2004 Aug;22(4):328-333.
BACKGROUND: Migraine is commonly associated with anxiety disorder. However, whether anxiolytic medicine or changes in anxiety levels affect the migraine attack is unclear. Buspirone, the agonist for 5-HT1A receptor, is... -
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- Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
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Kim JG, Kim MS, Lee S, Kim GT, Lee JD, Kim DG
- KMID: 2285334
- Korean J Physiol Pharmacol.
- 2007 Jun;11(3):113-119.
Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a... -
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- Association of Serotonin 1A Receptor Polymorphism with Variation in Health-Related Quality of Life in Korean Hemodialysis Patients
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Park HC, Park S, Choi HY, Lee JE, Park HY, Kim SH, Ha SK, Seok JH
- KMID: 2387143
- Psychiatry Investig.
- 2017 Jul;14(4):506-512.
- doi: 10.4306/pi.2017.14.4.506
OBJECTIVE: Hemodialysis patients may have psychological distress and reduced quality of life (QoL) related to chronic physical health problems. Genetic polymorphisms associated with reduced QoL in hemodialysis patients. The aim... -
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- Modulation of the Neuronal Activity of Vestibular Nuclear Neurons by 8-OH-DPAT
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Jeong HS, Jang MJ, Huang M, Park JS
- KMID: 2172336
- Chonnam Med J.
- 2005 Apr;41(1):19-24.
This study was aimed to investigate the effects of the 8-hydroxy-2-(di-N-propylamino) tetralin (8-OH- DPAT), a specific 5-HT1A receptor agonist on the spontaneous activity of medial vestibular nuclear neurons of the... -
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- Vilazodone for the Treatment of Major Depressive Disorder: Focusing on Its Clinical Studies and Mechanism of Action
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Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU
- KMID: 2316423
- Psychiatry Investig.
- 2015 Apr;12(2):155-163.
- doi: 10.4306/pi.2015.12.2.155
We tried to review and update clinical and preclinical studies evaluating vilazodone's role as an antidepressant for patients with major depressive disorder (MDD). In terms of its mechanism of actions,... -
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