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Fluoxetine Induces Apoptotic and Oxidative Neuronal Death Associated with The Influx of Copper Ions in Cultured Neuronal Cells

Hwang S, Kim JK

We examined the effect of fluoxetine, a selective serotonin reuptake inhibitor antidepressant, on neuronal viability in mouse cortical near-pure neuronal cultures. Addition of fluoxetine to the media for 24 hours...
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Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Bayoumi AB, Ikizgul O, Karaali CN, Bozkurt S, Konya D, Toktas ZO

Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs...
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Biomarkers in Drug Free Subjects with Depression : Correlation with Tryptophan

Samad N, Yasmin F, Manzoor N

OBJECTIVE: Depression is a prevalent condition that is costly to individuals and society. In view of a role of tryptophan (TRP), selenium (Se), vitamin D (Vit D), magnesium (Mg) and...
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Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report

Ochi S, Inoue S, Yoshino Y, Shimizu H, Iga JI, Ueno SI

Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails....
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Aripiprazole-induced Hepatitis: A Case Report

Castanheira L, Fernandes , Levy P, Coentre R

Aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-HT1A receptors. It is used in the treatment of schizophrenia and...
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Biological Aspects of Aggression and Violence in Schizophrenia

Cho W, Shin WS, An I, Bang M, Cho DY, Lee SH

Although the majority of patients with schizophrenia are not actually violent, an increased tendency toward violent behaviors is known to be associated with schizophrenia. There are several factors to consider...
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Selective serotonin reuptake inhibitor escitalopram inhibits 5-HT₃ receptor currents in NCB-20 cells

Park YS, Sung KW

Escitalopram is one of selective serotonin reuptake inhibitor antidepressants. As an S-enantiomer of citalopram, it shows better therapeutic outcome in depression and anxiety disorder treatment because it has higher selectivity...
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Korean Treatment Guideline on Pharmacotherapy of Co-existing Symptoms and Antipsychotics-related Side Effects in Patients with Schizophrenia

Yun JY, Lee JS, Kang SH, Nam B, Lee SJ, Lee SH, Choi J, Kim CH, Chung YC

OBJECTIVES: The current study covers a secondary revision of the guidelines for the pharmacotherapy of schizophrenia issued by the Korean Medication Algorithm for Schizophrenia (KMAP-SCZ) 2001, specifically for co-existing symptoms...
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Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study

Burr RL, Gu H, Cain K, Djukovic D, Zhang X, Han C, Callan N, Raftery D, Heitkemper M

  • KMID: 2460485
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):551-562.
  • doi: 10.5056/jnm19042
BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women...
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The Prevention of Contrast Induced Nephropathy by Sarpogrelate: a Prospective Randomized Controlled Clinical Trial

Ki YJ, Kwon SA, Kim HL, Seo JB, Chung WY

BACKGROUND: Although some strategies are used for prophylaxis of contrast induced nephropathy, their efficacy is not fully established. Sarpogrelate can relieve vasospasm and have anti-inflammatory action. This study examined whether...
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Apathy syndrome in a patient previously treated with selective serotonin reuptake inhibitors for depression

Kim HG, Koo BH, Lee SW, Cheon EJ

There is considerable overlap in the clinical presentations of apathy and depression. However, differential diagnosis between apathy and other psychiatric conditions, including depression and dementia, is important. In this report,...
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Gastroprokinetic agent, mosapride inhibits 5-HT₃ receptor currents in NCB-20 cells

Park YS, Sung KW

Mosapride accelerates gastric emptying by acting on 5-hydroxytryptamine type 4 (5-HTâ‚„) receptor and is frequently used in the treatment of gastrointestinal (GI) disorders requiring gastroprokinetic efficacy. We tested the effect...
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Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice

Nguyen HT, Cho DH, Jang SH, Han SK, Park SJ

The lamina II, also called the substantia gelatinosa (SG), of the trigeminal subnucleus caudalis (Vc), is thought to play an essential role in the control of orofacial nociception. Glycine and...
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Augmentation of Aripiprazole versus Bupropion on Specific Symptoms of Depression in Older Adult Patients : A Post-Hoc, Multi-Center, Open-Label, Randomized Study

Jo S, Cheon E, Lee K, Koo B, Park Y, Lee J, Lee S, Sung H

OBJECTIVES: The purpose of this study was to compare aripiprazole versus bupropion augmentation therapy in older adult patients with major depressive disorder unresponsive to selective serotonin reuptake inhibitors(SSRIs). METHODS: This is...
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Prescription Pattern of Antidepressants in Korea for Major Neurological Disorders: Before the Policy Change in 2017

Park Y, Baek ES, Choi J, Lee J, Lee SH, Park KW

BACKGROUND: It is well known that patients with neurological disorders are vulnerable to depression. However, in Korea, National Health Insurance services had banned non-psychiatrists from prescribing antidepressants for more than...
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Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

Kurmuş GI, Gönül M, Canpolat F, Yılmazer , Cankurtaran ES

BACKGROUND: Psychological factors such as stress, depression, and anxiety have been documented to contribute to the development of lesions in lichen planus (LP). OBJECTIVE: To evaluate the relationship between serotonin expression...
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Predicting Behavior Problems in Korean Preschoolers: Interactions of the SLC6A4 Gene and Maternal Negative Affectivity

Ha J, Jun HJ, Shin H, Chung IJ, Park E, Min SK, Kim E

OBJECTIVE: This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children. METHODS: Study participants comprised 143 preschoolers and...
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The Evaluation of Drug Utilization Review on Potentially Inappropriate Medications for Elderly Patients in a Tertiary Hospital

Cho YH, Kim KJ

OBJECTIVE: South Korea made a list of potentially inappropriate medications (PIMs) for elderly patients in 2015 and has prompted medical professionals to prescribe proper medication by using the drug utilization...
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Improvement of Post Stroke Echolalia after Using Selective Serotonin Reuptake Inhibitors

Bae H, Park J, Yang Y

No abstract available.
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Gender Differences in the Clinical Manifestation of Depression and Related Neurotransmitters

Yoon S, Chang SM

Depression is almost twice as prevalent in women than men. Atypical symptoms, somatic complaints, and comorbid anxiety disorders are more common in women, whereas suicide and comorbid substance use disorders...
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